Perspectives of South African youth in the development of an implant for HIV prevention
| Autor: | Tsholofelo Malapane, Kgahlisho Manenzhe, Alexandra M. Minnis, Millicent Atujuna, Emily A Krogstad, Mary Kate Shapley-Quinn, Elizabeth T. Montgomery, Linda-Gail Bekker, Sheily Ndwayana, Ariane van der Straten |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adolescent implant Anti-HIV Agents Human immunodeficiency virus (HIV) Black People HIV Infections medicine.disease_cause South Africa Young Adult 03 medical and health sciences Pre-exposure prophylaxis 0302 clinical medicine Pregnancy medicine Humans 030212 general & internal medicine product development Research Articles pre‐exposure prophylaxis Drug Implants business.industry Biodegradable implants Implant design Public Health Environmental and Occupational Health Focus Groups 030112 virology Focus group 3. Good health High uptake Infectious Diseases Family medicine Female Pre-Exposure Prophylaxis Implant Contraceptive implant business Research Article |
| Zdroj: | Journal of the International AIDS Society |
| ISSN: | 1758-2652 |
| DOI: | 10.1002/jia2.25170 |
| Popis: | Introduction Implants are a new dosage form in development for HIV pre‐exposure prophylaxis (PrEP) with potential for high adherence given that they are provider‐administered and are intended for long‐acting protection. Integrating end‐user preference into early stage product development may further overcome challenges with future product uptake and adherence. Hence, we sought to optimize the design of a PrEP implant in early‐stage development by gathering opinions about implant attributes from potential end‐users in South Africa. Methods We conducted 14 focus group discussions (FGDs) with young women and men aged 18 to 24 in Cape Town and Soshanguve, South Africa, inviting participants into discussion as co‐designers. FGDs were homogenous by gender and previous implant experience. During FGDs, we showed prototype devices and followed a semi‐structured guide with questions on history of contraceptive implant use, preferences for physical characteristics of an implant, implant biodegradability, insertion process, participant‐driven ideas for implant design, and social adoption considerations. FGDs were facilitated in English, isiXhosa, Tswana, isiZulu, or Tsonga, audio‐recorded, transcribed into English, and qualitatively coded and analysed. Results In this qualitative sample of 105 youth (68 women and 37 men), 58 participants were from Soshanguve and 47 from Cape Town, and 23% had previously used contraceptive implants. Participants expressed preferences for several implant design features; specifically, longer duration (≥6 months) was more important to most participants than the size or number of devices implanted. A majority preferred a flexible versus stiff implant to minimize palpability, thereby increasing discreetness and comfort. Nearly all participants favoured a biodegradable implant to avoid removal and thus reduce clinic visits. Concerns about the implant centred on its possible side effects and the “plastic” look of the prototype displayed for demonstration. Conclusions This study offers preliminary insights into an implant for HIV prevention that provides long‐lasting protection may be well received among young South Africans. Additionally, flexibility, discreetness, and biodegradability may increase acceptability of the implant. Such end–user feedback is being incorporated into current implant designs in the hope of creating an effective long‐acting PrEP product that is likely to achieve high uptake and adherence in target populations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|