Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study
| Autor: | Raquel Granell, Gibran Hemani, George Davey Smith, Daniel H Higbee, James W. Dodd |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Oncology Male medicine.medical_specialty Polymorphism Single Nucleotide 03 medical and health sciences FEV1/FVC ratio Pulmonary Disease Chronic Obstructive Diseases of the respiratory system 0302 clinical medicine Cognition Risk Factors Internal medicine Mendelian randomization medicine Dementia Humans 030212 general & internal medicine Risk factor Cognitive decline Lung COPD RC705-779 business.industry Research Confounding Mendelian Randomization Analysis Middle Aged medicine.disease Respiratory Function Tests respiratory tract diseases 030104 developmental biology Multivariate Analysis Female business |
| Zdroj: | BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-7 (2021) BMC Pulmonary Medicine Higbee, D H, Granell, R, Hemani, G, Davey Smith, G & Dodd, J 2021, ' Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study ', BMC Pulmonary Medicine, vol. 21, no. 1, 246 . https://doi.org/10.1186/s12890-021-01611-6 |
| ISSN: | 1471-2466 |
| DOI: | 10.1186/s12890-021-01611-6 |
| Popis: | Background Observational studies show an association between reduced lung function and impaired cognition. Cognitive dysfunction influences important health outcomes and is a precursor to dementia, but treatments options are currently very limited. Attention has therefore focused on identifying modifiable risk factors to prevent cognitive decline and preserve cognition. Our objective was to determine if lung function or risk of COPD causes reduced cognitive function using Mendelian randomization (MR). Methods Single nucleotide polymorphisms from genome wide association studies of lung function and COPD were used as exposures. We examined their effect on general cognitive function in a sample of 132,452 individuals. We then performed multivariable MR (MVMR), examining the effect of lung function before and after conditioning for covariates. Results We found only weak evidence that reduced lung function (Beta − 0.002 (SE 0.02), p-value 0.86) or increased liability to COPD (− 0.008 (0.008), p-value 0.35) causes lower cognitive function. MVMR found both reduced FEV1 and FVC do cause lower cognitive function, but that after conditioning for height (− 0.03 (0.03), p-value 0.29 and − 0.01 (0.03) p-value 0.62, for FEV1 and FVC respectively) and educational attainment (− 0.03 (0.03) p-value 0.33 and − 0.01 (0.02), p-value 0.35) the evidence became weak. Conclusion We did not find evidence that reduced lung function or COPD causes reduced cognitive function. Previous observational studies are probably affected by residual confounding. Research efforts should focus on shared risk factors for reduced lung function and cognition, rather than lung function alone as a modifiable risk factor. |
| Databáze: | OpenAIRE |
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