Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak

Autor: Julia Hinzmann, Meike Pahlmann, Liana E. Kafetzopoulou, Rosemary Giwa, Miles W. Carroll, Racheal Omiunu, Kyriakos Efthymiadis, Michael Airende, Sophie Duraffour, Kelly Ohis Iraoyah, Chris Aire, Pierre Formenty, A Thielebein, Christopher Ojemiega Iruolagbe, Blessing Osiemi, Patience Akhilomen, Sarah Lumley, Donatus I Adomeh, Ganiyu Igenegbale, Cyril O Erameh, Ekene B. Muoebonam, R Vipond, Sylvanus Okogbenin, Chikwe Ihekweazu, Paulson Ebhodaghe, E O Yerumoh, Peter E Akhideno, George O. Akpede, Peter O. Okokhere, Deborah U. Ehichioya, E Isibor, Grace Okonofua, Jacqueline Agbukor, Nosa Akpede, Benevolence Ebo, Steven T. Pullan, Rita Esumeh, David M. Wozniak, Stephan Lorenzen, Roger Hewson, Emmanuel Omomoh, Martha Okonofua, Marc A. Suchard, R Enigbe, Jennifer Oyakhilome, Anieno Ekanem, Ikponmwosa Odia, F Koenig, Lisa Oestereich, Thomas Olokor, D Schachten, Yemisi Ighodalo, George Odigie, Mojeed Rafiu, D. Asogun, Julian A. Hiscox, Philippe Lemey, Ephraim Ogbaini-Emovon, Solomon Ehikhametalor, John Aiyepada, Ekaete Tobin, Dhamari Naidoo, J Matjeschk, Rebecca O Atafo, Stephan Günther
Přispěvatelé: Informatics and Applied Informatics, Artificial Intelligence
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Science
Science (New York, N.Y.), vol 363, iss 6422
ISSN: 0036-8075
Popis: Mobile detection of Lassa virus Lassa fever is a hemorrhagic viral disease endemic to West Africa. Usually, each year sees only a smattering of cases reported, but hospitalized patients risk a 15% chance of death. Responding to fears that a 10-fold surge in cases in Nigeria in 2018 signaled an incipient outbreak, Kafetzopoulou et al. performed metagenomic nanopore sequencing directly from samples from 120 patients (see the Perspective by Bhadelia). Results showed no strong evidence of a new strain emerging nor of person-to-person transmission; rather, rodent contamination was the main source. To prevent future escalation of this disease, we need to understand what triggers the irruption of rodents into human dwellings. Science , this issue p. 74 ; see also p. 30
Databáze: OpenAIRE