The immunology of the human foetal pancreas aged 8–13 gestational weeks
| Autor: | C. G. Koffman, I. McColl, L. C. Koo Seen Lin, Kenneth I. Welsh |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Ductal cells Gestational Age Immunophenotyping Immunoenzyme Techniques Fetus Internal medicine MHC class I medicine Macrophage Humans Pancreas geography Transplantation Hematology geography.geographical_feature_category biology business.industry Histocompatibility Antigens Class I Histocompatibility Antigens Class II Antibodies Monoclonal Islet medicine.anatomical_structure Endocrinology Immunology biology.protein Immunohistochemistry business |
| Zdroj: | Transplant International. 4:195-199 |
| ISSN: | 1432-2277 0934-0874 |
| DOI: | 10.1111/j.1432-2277.1991.tb01979.x |
| Popis: | The expression of MHC class I and class II antigens by the human foetal pancreas (HFP) during the first trimester is poorly documented. Using immunohistochemical techniques, we analysed 37 HFPs aged 8–13 gestatitional weeks (gw) and compared the results with those of 9 HFPs aged 14–16 gw. In all of the specimens, the ductal cells were class I- and class II-negative. Islets and endothelial cells expressed class I but were class II-. Interstitial class II+ cells included macrophages, B lymphocytes and dendritic-like cells that were negative for macrophage markers. While the frequency of class II+ cells in the HFP remained constant from 8 to 13 gw, a threefold increase was observed from the end of the 13th gw to the 16th gw. In conclusion, the lower density of interstitial class II+ cells in HFPs aged 8–13 gw indicates that immunomodulation is likely to be more successful in this age group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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