Clinical correlates of sudomotor dysfunction in patients with type 2 diabetes and peripheral neuropathy
| Autor: | Kolly Anish, Boppana Rakesh, Goel Amit, Biswas Anupam, C Shivaprasad, Yalamanchi Aiswarya |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Small Fiber Neuropathy 030209 endocrinology & metabolism Type 2 diabetes Autonomic Nervous System 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetic Neuropathies Interquartile range Internal medicine Diabetes mellitus Internal Medicine medicine Humans In patient integumentary system business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Sudomotor Peripheral neuropathy Diabetes Mellitus Type 2 Cardiology Female business 030217 neurology & neurosurgery Sudomotor dysfunction |
| Zdroj: | Diabetes research and clinical practice. 139 |
| ISSN: | 1872-8227 |
| Popis: | To investigate the factors associated with abnormal electrochemical skin conductance (ESC) in patients with type 2 diabetes mellitus (T2D) and early diabetic peripheral neuropathy (DPN).We recruited 523 consecutive patients with T2D (median age: 50 [interquartile range: 16] years; median T2D duration: 4 [5] years). Sudomotor dysfunction was defined as an ESC 60 µS, and DPN as a neuropathy disability score (NDS) ≥6. Logistic regression was performed to determine the predictors of sudomotor dysfunction in patients with DPN.The prevalence of sudomotor dysfunction was 29% for all patients and 84.5% for patients with DPN. A significant negative correlation was observed between the NDS and ESC measurements (r = -0.52, p 0.0001). In the univariate analysis, abnormal ESC measures were associated with age, diabetes duration, glycated hemoglobin, diabetic retinopathy, insulin therapy, and foot abnormalities. In the multivariate analysis, ESC abnormalities were associated with age, diabetes duration, glycated hemoglobin levels, insulin therapy, and foot deformities. There was a robust association between foot deformities and abnormal ESC (p = 0.049; odds ratio = 16.02) in patients with DPN.Sudomotor dysfunction is highly prevalent in patients with T2D, especially in those with DPN. Various diabetes-related factors were linked to lower ESC values, indicating an association between chronic hyperglycemia and sudomotor function. We also observed a strong relationship between foot deformities and ESC abnormalities. We conclude that the factors associated with DPN are also relevant to sudomotor dysfunction. |
| Databáze: | OpenAIRE |
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