Glucosylated liposomes as drug delivery systems of usnic acid to address bacterial infections
| Autor: | Barbara Altieri, Luisa Giansanti, Alessandro Mauceri, Giovanna Mancini, Antonella Piozzi, Iolanda Francolini |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Glycosylation
Surface Properties medicine.drug_class Antibiotics Microbial Sensitivity Tests 02 engineering and technology 01 natural sciences Microbiology chemistry.chemical_compound (+)-Usnic acid Drug Delivery Systems Colloid and Surface Chemistry Staphylococcus epidermidis biofilm 0103 physical sciences Staphylococcus epidermidis medicine Positive charge Cationic liposome Particle Size Physical and Theoretical Chemistry Benzofurans Liposome Molecular Structure 010304 chemical physics usnic acid Biofilm Usnic acid Biofilm matrix Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology Antimicrobial liposomes bacterial infections biofilms Anti-Bacterial Agents chemistry Liposomes Drug delivery 0210 nano-technology Biotechnology |
| Popis: | Because of the increased incidence of infections caused by resistant pathogens, due to the intensive use of antibiotics, there is an urgent need to develop new therapeutic strategies against bacteria, possibly based on non conventional drugs. (+)-Usnic acid is a natural compound that exerts a potent antibacterial activity, however its clinical application is hampered by its scarce solubility in water. Usnic acid was included, by both passive and active loading techniques, in liposomes containing structurally related glucosylated amphiphiles. Liposome formulations were characterized from the physicochemical point of view and their activity against biofilm associated Staphylococcus epidermidis was also evaluated. The inclusion of usnic acid in glucosylated cationic liposomes promotes its penetration in biofilm matrix with a consequent increase of its antimicrobial activity. The effect of both cationic charge and sugar residue seems to be synergistic. |
| Databáze: | OpenAIRE |
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