Epithelial-mesenchymal transition in hepatocellular carcinoma
| Autor: | Mara Hau, Heidemarie Huber, Wolfgang Mikulits, Christoph Kornauth, Doris Schneller, Gudrun Zulehner, Michaela Petz, Markus Grubinger, Georg Machat, Franziska van Zijl |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Cellular differentiation Article Epithelium Metastasis Mesoderm 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Humans Epithelial–mesenchymal transition 030304 developmental biology 0303 health sciences Metaplasia business.industry Mesenchymal stem cell Liver Neoplasms Wnt signaling pathway Cancer Cell Differentiation General Medicine Cell Dedifferentiation medicine.disease digestive system diseases 3. Good health Cell Transformation Neoplastic Tumor progression 030220 oncology & carcinogenesis Hepatocellular carcinoma embryonic structures business |
| Zdroj: | Future Oncology; Vol 5 |
| ISSN: | 1479-6694 |
| DOI: | 10.2217/FON.09.91 |
| Popis: | The transition of epithelial cells to a mesenchymal phenotype is of paramount relevance for embryonic development and adult wound healing. During the past decade, the epithelial–mesenchymal transition (EMT) has been increasingly recognized to occur during the progression of various carcinomas such as hepatocellular carcinoma (HCC). Here, we focus on EMT in both experimental liver models and human HCC, emphasizing the underlying molecular mechanisms which show partial recurrence of embryonic programs such as TGF-β and Wnt/ β-catenin signaling, including collaboration with hepatitis viruses. We further discuss the differentiation repertoire of malignant hepatocytes with respect to the potential acquisition of stemness, and the involvement of the mesenchymal to epithelial transition, the reversal of EMT, in cancer dissemination and metastatic colonization. The strong evidence for EMT in HCC patients demands novel strategies in pathological assessments and therapeutic concepts to efficiently combat HCC progression. |
| Databáze: | OpenAIRE |
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