Beneficial Effects of N-Acetyl-L-cysteine or Taurine Pre- or Post-treatments in the Heart, Spleen, Lung, and Testis of Hexavalent Chromium-Exposed Mice
| Autor: | İffet İpek Boşgelmez, Gülin Güvendik |
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| Rok vydání: | 2018 |
| Předmět: |
Chromium
Male medicine.medical_specialty Taurine Endocrinology Diabetes and Metabolism Clinical Biochemistry Spleen 010501 environmental sciences 01 natural sciences Biochemistry Inorganic Chemistry Lipid peroxidation Mice 03 medical and health sciences chemistry.chemical_compound Internal medicine Testis medicine Animals Sulfhydryl Compounds Hexavalent chromium Lung 0105 earth and related environmental sciences chemistry.chemical_classification 0303 health sciences 030302 biochemistry & molecular biology Biochemistry (medical) Heart General Medicine Acetylcysteine Endocrinology NPSH medicine.anatomical_structure chemistry Toxicity Thiol Lipid Peroxidation |
| Zdroj: | Biological Trace Element Research. 190:437-445 |
| ISSN: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-018-1571-z |
| Popis: | Hexavalent chromium[Cr(VI)] compounds may induce toxic effects, possibly via reactive intermediates and radicals formed during Cr(VI) reduction. In this study, we probed the possible effects of N-acetyl-L-cysteine (NAC) and taurine pre- or post-treatments on Cr(VI)-induced changes in lipid peroxidation and nonprotein thiols (NPSH) in mice heart, lung, spleen, and testis tissues. The mice were randomly assigned to six groups, consisting of control, Cr(VI)-exposed (20 mg Cr/kg, intraperitoneal ,ip), NAC (200 mg/kg, ip) as pre-treatment and post-treatment, and taurine (1 g/kg, ip) pre-treatment and post-treatment groups. Lipid peroxidation and NPSH levels were determined and the results were compared with regard to tissue- and antioxidant-specific basis. Exposure to Cr(VI) significantly increased lipid peroxidation in all tissues as compared to the control (p |
| Databáze: | OpenAIRE |
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