Normal Values for Parotid Gland and Submandibular-Sublingual Salivary Gland Complex Uptake of 99mTechnetium Pertechnetate using SPECT in Mice with Respect to Age, Sex, and Circadian Rhythm
| Autor: | Kai Huang, Winfried Brenner, J. R. Aschenbach, Eleonore L. Huang, Ingo G. Steffen, Janet F. Eary, Mathias Lukas, Nicola Beindorff |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Aging Pertechnetate Submandibular Gland Normal values Sublingual Salivary Gland 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Reference Values Internal medicine medicine Animals Parotid Gland Radiology Nuclear Medicine and imaging Circadian rhythm Sodium Pertechnetate Tc 99m Parotis Tomography Emission-Computed Single-Photon Sex Characteristics biology Salivary gland business.industry Biological Transport 030206 dentistry General Medicine biology.organism_classification Parotid gland Circadian Rhythm Mice Inbred C57BL medicine.anatomical_structure Endocrinology chemistry 030220 oncology & carcinogenesis Female business Sex characteristics |
| Zdroj: | Nuklearmedizin. Nuclear medicine. 58(1) |
| ISSN: | 2567-6407 |
| Popis: | Aim The aim of this study was to establish normal values for parotid gland (PG) and submandibular-sublingual salivary gland complex (SSC) uptake of 99mtechnetium pertechnetate (99mTcO4) as a function of age, sex and circadian rhythm in mice. Methods In 12 female (F) and 12 male (M) C57BL/6N mice, nine consecutive SPECT images of 10 min each were acquired as dynamic acquisitions beginning 5 min after intravenous injection of 80 MBq 99mTcO4. Each mouse was imaged in follow-up studies at 1, 3, 6, 12 and 24 months of age. In order to assess for physiologic changes related to circadian rhythm, animals were imaged during light (sleeping phase) as well as during night conditions (awake phase). The percentage tracer uptake of the injected activity is expressed as median %ID. Results Maximum 99mTcO4 uptake occurred earlier in PG at 11 min compared to SSC at 79 min (p Conclusion Uptake patterns differed among PG and SSC with a significant impact of age and sex while circadian rhythm had no significant influence. Therefore, design of salivary gland studies in mice using 99mTcO4 should consider age and sex as relevant factors. |
| Databáze: | OpenAIRE |
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