Biocytin-Based pH-Stimuli Responsive Supramolecular Multivariant Hydrogelator for Potential Applications
| Autor: | Samala Murali Mohan Reddy, Ganesh Shanmugam, Niraikulam Ayyadurai, George Augustine |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
chemistry.chemical_classification
Stimuli responsive Biomolecule Biochemistry (medical) technology industry and agriculture Biomedical Engineering Supramolecular chemistry macromolecular substances 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology complex mixtures 01 natural sciences Small molecule 0104 chemical sciences Biomaterials chemistry.chemical_compound chemistry Biotin Biocytin Self-healing hydrogels Biophysics 0210 nano-technology Intracellular |
| Zdroj: | ACS applied bio materials. 1(5) |
| ISSN: | 2576-6422 |
| Popis: | Self-assembly is one of the important and fruitful methods to develop various biomaterials, especially hydrogels, from biologically important small molecules. Two such molecules are d-biotin (B-vitamin), which plays several vital roles in biology and is used in the biomedical field, and biocytin, which is used as an intracellular marker and also to identify neurons. Despite the significance of these biomolecules, their usage in the form of hydrogel is very limited. Herein, for the first time, a pH-stimuli responsive supramolecular hydrogel based on biocytin, an amidation product of d-biotin and l-lysine, has been developed to extend the use of d-biotin, biocytin, and l-lysine in the biomedical field. The newly developed hydrogelator such as Nα-(fluorenylmethoxycarbonyl)-d-biocytin) [FmB] exhibited pH-dependent hydrogelation and exhibited a thixotropic and thermally reversible nature at a physiological pH, while it displayed a supergelator nature at an acidic pH. Electron microscopic analysis of FmB hydrog... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|