Phyto-mediated synthesized multifunctional Zn/CuO NPs hybrid nanoparticles for enhanced activity for kidney cancer therapy: A complete physical and biological analysis
| Autor: | Yifeng Xue, Zhengfei Shan, Zhonglian Li, Guoxin Yu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cell Survival
Biophysics Metal Nanoparticles Nanoparticle chemistry.chemical_element Antineoplastic Agents 02 engineering and technology Zinc 010402 general chemistry 01 natural sciences Cell Line Metal Microscopy Electron Transmission X-Ray Diffraction Spectroscopy Fourier Transform Infrared Humans Radiology Nuclear Medicine and imaging Viability assay Particle Size Cytotoxicity Rosaceae Radiation Radiological and Ultrasound Technology Plant Extracts Chemistry Green Chemistry Technology 021001 nanoscience & nanotechnology Kidney Neoplasms 0104 chemical sciences visual_art Cancer cell Microscopy Electron Scanning visual_art.visual_art_medium Crystallite Particle size 0210 nano-technology Copper Nuclear chemistry |
| Zdroj: | Journal of Photochemistry and Photobiology B: Biology. 186:131-136 |
| ISSN: | 1011-1344 |
| DOI: | 10.1016/j.jphotobiol.2018.07.004 |
| Popis: | Cancer in human society is one of the most problematic health issue responsible for outnumbered deaths worldwide. The consumption of developed NPs in cancer diagnosis is a rapidly emerging field of bio-medical nanotechnology. Recent years, greener synthesized metal oxide hybrid nanoparticles have attracted great attention in cytotoxicity to different cancer therapy. Herein, we report that Duchesnea indica plant mediated green synthesis plant extract mediated Zn doped CuO (Zn/CuO) nanoparticles (NPs) prepared by hydrothermal method and these physico-chemical properties were characterized by XRD, UV-DRS, FTIR, and SEM with EDAX analytical techniques. The XRD pattern findings indicated that the crystal structure of the base CuO matrix are not distorted by the substitution of Cu2+ (0.73 A) ions by Zn2+ (0.65 A) ions. The average crystallite size of undoped and Zn/CuO NPs samples are found to be in between the range of 23 to 36 nm. And we can see that the Zn/CuO NPs are large aggregates, containing small particles with sizes of 100–300 nm with spherical shaped morphology by SEM and TEM microscopic images. The normal cell viability and cancer cell inhibition results on A-498 cancer cells and also normal human epithelial cells exhibited that no significant changes in the cell viability with normal kidney epithelial cells and doped NPs given excellent cell inhibition treated on A-498 kidney tumor cells. |
| Databáze: | OpenAIRE |
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