Synthesis and anticancer activity of new 1-substituted-6H-pyrido[4,3-b]carbazole derivatives
| Autor: | Katarzyna Szczaurska-Nowak, Beata Tylińska, Joanna Wietrzyk, Henryk Mastalarz, Ryszard Jasztold-Howorko |
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| Rok vydání: | 2008 |
| Předmět: |
A549 cell
Cisplatin Human lung cancer Carbazole Stereochemistry Cell Survival Carbazoles Pharmaceutical Science Cancer Antineoplastic Agents Olivacine medicine.disease In vitro chemistry.chemical_compound chemistry Cell culture Cell Line Tumor Drug Discovery medicine Humans Ellipticines Drug Screening Assays Antitumor medicine.drug |
| Zdroj: | Archiv der Pharmazie. 341(6) |
| ISSN: | 0365-6233 |
| Popis: | This study examines the synthesis and cytostatic activity of new 5,6-dimethyl-1-substituted-6H-pyrido[4,3-b]carbazole derivatives. Their structures were confirmed by 1 H-NMR and elemental analysis. Seven of the new compounds were tested by the SRB method in vitro against human lung cancer (A549) and human kidney cancer (A498) cell lines. Biological tests indicated remarkable cytostatic effects of four compounds tested in comparison with ellipticine and cisplatin as reference drugs. One particular compound 3c was about four times more active on A498 than ellipticine with similar activity on the A549 cell line, and outperformed cisplatin activity on both tumor cell lines. |
| Databáze: | OpenAIRE |
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