Vulnerability to depression: from brain neuroplasticity to identification of biomarkers
| Autor: | Aurélie Blugeot, Brigitte Zeau, Chrystel Becker, Christophe Bernard, Amandine Mouchard, Cyril Rivat, Elodie Bouvier, Jenny Molet, Jean Jacques Benoliel |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Competitive Behavior Hypothalamo-Hypophyseal System Imipramine Hippocampus Pituitary-Adrenal System Tropomyosin receptor kinase B Antidepressive Agents Tricyclic Social Environment Amygdala Rats Sprague-Dawley chemistry.chemical_compound Basal (phylogenetics) Corticosterone Internal medicine Neuroplasticity medicine Animals Longitudinal Studies Depression (differential diagnoses) Swimming Cell Proliferation Neurons Depressive Disorder Neuronal Plasticity General Neuroscience Brain-Derived Neurotrophic Factor Neurogenesis Brain Articles Rats Endocrinology medicine.anatomical_structure chemistry Taste Psychology Neuroscience Biomarkers Stress Psychological |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(36) |
| ISSN: | 1529-2401 |
| Popis: | A stressful event increases the risk of developing depression later in life, but the possible predisposing factors remain unknown. Our study aims to characterize latent vulnerability traits underlying the development of depressive disorders in adult animals. Four weeks after a priming stressful event, serum corticosterone concentration returned to control values in all animals, whereas the other biological parameters returned to basal level in only 58% of animals (called nonvulnerable). In contrast, 42% of animals displayed persistent decreased serum and hippocampus BDNF concentrations, reduced hippocampal volume and neurogenesis, CA3 dendritic retraction and decrease in spine density, as well as amygdala neuron hypertrophy, constituting latent vulnerability traits to depression. In this group, called vulnerable, a subsequent mild stress evoked a rise of serum corticosterone levels and a “depressive” phenotype, in contrast to nonvulnerable animals. Intracerebroventricular administration of 7,8-dihydroxyflavone, a selective TrkB receptor agonist, dampened the development of the “depressive” phenotype. Our results thus characterize the presence of latent vulnerability traits that underlie the emergence of depression and identify the association of low BDNF with normal corticosterone serum concentrations as a predictive biomarker of vulnerability to depression. |
| Databáze: | OpenAIRE |
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