Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics
| Autor: | Xiaomin Yuan, Huize Liu, Xiaoyong Wang, Tuo Chen, Guoping Shi, Yang Ding, Yajun Liu, Hong-tao Shang, Jun Xiao, Qiong Wang, Baosheng Wang, Shijia Liu, Weiwei Liu, Ziqian Xia, Jin-Yong Zhou, Zhenglan Duan, Yugen Chen, Zhaofeng Shen, Biqing Chen, Bo-Lin Yang, Lei Zhu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Proteomics Microbiology (medical) medicine.medical_specialty Adolescent multi-omics analyses RC799-869 Anxiety Gut flora medicine.disease_cause Microbiology Gastroenterology Feces Mice Young Adult Internal medicine Brain-Gut Axis medicine Metabolome Prevotella Animals Humans Metabolomics Prospective Studies Colitis microbiota-gut-brain axis Depression (differential diagnoses) Aged ulcerative colitis Bacteria biology Depression Streptococcus Middle Aged Diseases of the digestive system. Gastroenterology medicine.disease biology.organism_classification Ulcerative colitis Gastrointestinal Microbiome Infectious Diseases Colitis Ulcerative medicine.symptom Research Article Research Paper |
| Zdroj: | Gut Microbes, Vol 13, Iss 1 (2021) Gut Microbes article-version (VoR) Version of Record |
| ISSN: | 1949-0984 1949-0976 |
| DOI: | 10.1080/19490976.2021.1987779 |
| Popis: | Patients with ulcerative colitis (UC) have a high prevalence of mental disorders, such as depression and anxiety. Gut microbiota imbalance and disturbed metabolism have been suggested to play an important role in either UC or mental disorders. However, little is known about their detailed multi-omics characteristics in patients with UC and depression/anxiety. In this prospective observational study, 240 Chinese patients were enrolled, including 129 patients with active UC (69 in Phase 1 and 60 in Phase 2; divided into depression/non-depression or anxiety/non-anxiety groups), 49 patients with depression and anxiety (non-UC), and 62 healthy people. The gut microbiota of all subjects was analyzed using 16S rRNA sequencing. The serum metabolome and proteome of patients with UC in Phase 2 were analyzed using liquid chromatography/mass spectrometry. Associations between multi-omics were evaluated by correlation analysis. The prophylactic effect of candidate metabolites on the depressive-like behavior of mice with colitis was investigated. In total, 58% of patients with active UC had depression, while 50% had anxiety. Compared to patients with UC without depression/anxiety, patients with UC and depression/anxiety had lower fecal microbial community richness and diversity, with more Lactobacillales, Sellimonas, Streptococcus, and Enterococcus but less Prevotella_9 and Lachnospira. Most metabolites (e.g., glycochenodeoxycholate) were increased in the serum, while few metabolites, including 2ʹ-deoxy-D-ribose and L-pipecolic acid, were decreased, accompanied by a general reduction in immunoglobulin proteins. These related bacteria, metabolites, and proteins were highly connected. A prophylactic administration of 2ʹ-deoxy-D-ribose and L-pipecolic acid significantly reduced the depressive-like behaviors in mice with colitis and alleviated the inflammatory cytokine levels in their colon, blood and brain. This study has identified a comprehensive multi-omics network related to depression and anxiety in active UC. It is composed of a certain set of gut microbiota, metabolites, and proteins, which are potential targets for clinical intervention for patients with UC and depression/anxiety. |
| Databáze: | OpenAIRE |
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