Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets
| Autor: | V. Cools, A. Houvenaghel, Eric Cox |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
Diarrhea
medicine.drug_class Chlorpromazine Swine Weanling Calcium channel blocker Propranolol Pharmacology drugs Clonidine Microbiology Antidiarrhoeal medicine Escherichia coli Animals Escherichia coli Infections Swine Diseases General Veterinary business.industry Gastroenteritis Transmissible of Swine pigs General Medicine transmissible gastroenteritis virus virology Disease Models Animal Animals Newborn Verapamil Vomiting Female medicine.symptom business bacteriology medicine.drug |
| Zdroj: | Veterinary Research Communications |
| ISSN: | 1573-7446 0165-7380 |
| Popis: | In 45 newly-weaned 3 to 4-week-old piglets, diarrhoea was induced by a combined infection with transmissible gastroenteritis (TGE) virus and enterotoxigenic E. coli (ETEC) strains. In untreated control animals this dual inoculation resulted in profuse diarrhoea, vomiting, hypovolaemic shock and death of 77% of the animals within five days of TGE virus inoculation. Antisecretory drugs were administered intramuscularly for three consecutive days after experimental infection. The neurolepticum chlorpromazine, at 2 mg/kg/24 h, resulted in a significant inhibition of diarrhoea and vomiting, and in an increase in weight gain and survival. Sedation and hypothermia, however, were serious side-effects. The alpha 2 agonist clonidine, at 80 micrograms/kg/12 h, induced a significant antidiarrhoeal effect and a reduction in mortality. The drug, however, provoked decreased activity of alpha 2-adrenergic excitation and incoordination. The beta-adrenergic antagonist propranolol, at 0.33 mg/kg/8 h, and the calcium channel blocker verapamil, at 2 mg/kg/8 h, had no beneficial effect on the experimentally induced diarrhoea. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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