Laser-assisted nanoparticle delivery to promote skin absorption and penetration depth of retinoic acid with the aim for treating photoaging
| Autor: | Woan-Ruoh Lee, Tse-Hung Huang, Sindy Hu, Ahmed Alalaiwe, Pei-Wen Wang, Pei-Chi Lo, Jia-You Fang, Shih-Chun Yang |
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| Rok vydání: | 2022 |
| Předmět: |
Skin Absorption
Pharmaceutical Science Mice Nude Tretinoin Lasers Solid-State Carbon Dioxide Administration Cutaneous Skin Diseases Collagen Type I Matrix Metalloproteinases Elastin Mice Polylactic Acid-Polyglycolic Acid Copolymer Solvents Animals Humans Nanoparticles Tissue Distribution Emulsions Skin |
| Zdroj: | International journal of pharmaceutics. 627 |
| ISSN: | 1873-3476 |
| Popis: | Retinoic acid (RA) is an approved treatment for skin photoaging induced by ultraviolet (UVA). Topically applied RA is mainly located in the stratum corneum (SC) with limited diffusion into the deeper strata. A delivery system capable of facilitating dermal delivery and cellular internalization for RA is critical for a successful photoaging therapy. Two delivery approaches, namely nanoparticles and laser ablation, were combined to improve RA's absorption efficacy and safety. The nanoparticle absorption enhancement by the lasers was compared between full-ablative (Er:YAG) and fractional (CO |
| Databáze: | OpenAIRE |
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