Neandertals Likely Kept Their Genes to Themselves
| Autor: | Mario Chech, Göran Possnert, André Langaney, Svante Pääbo, David Serre, Maja Paunović, Philippe Mennecier, Maria Teschler-Nicola, Michael Hofreiter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Mitochondrial DNA
Evolution QH301-705.5 Molecular Sequence Data mitochondrial DNA Neandertal fossils early modern humans Neanderthal genome project Biology Molecular Biology/Structural Biology DNA Mitochondrial Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Peuplement Anthropology Physical Homme moderne Evolution Molecular Génétique humaine Genetic drift Homo (Human) Animals Humans Biology (General) ddc:599.9 DNA Primers Genetics Models Statistical Base Sequence General Immunology and Microbiology General Neuroscience Homo Neandertalensis Paleontology Paleogenetics Hominidae DNA Sequence Analysis DNA biology.organism_classification Genetics Population Ancient DNA Evolutionary biology Paleoanthropology Cave bear Gene pool General Agricultural and Biological Sciences Research Article |
| Zdroj: | PLoS Biology, Vol 2, Iss 3, p E57 (2004) Early Modern Humans at the Moravian Gate ISBN: 9783211235881 PLoS Biology PLOS Biology, Vol. 2, No 3 (2004) pp. 313-317 |
| ISSN: | 1545-7885 1544-9173 |
| Popis: | The retrieval of mitochondrial DNA (mtDNA) sequences from four Neandertal fossils from Germany, Russia, and Croatia has demonstrated that these individuals carried closely related mtDNAs that are not found among current humans. However, these results do not definitively resolve the question of a possible Neandertal contribution to the gene pool of modern humans since such a contribution might have been erased by genetic drift or by the continuous influx of modern human DNA into the Neandertal gene pool. A further concern is that if some Neandertals carried mtDNA sequences similar to contemporaneous humans, such sequences may be erroneously regarded as modern contaminations when retrieved from fossils. Here we address these issues by the analysis of 24 Neandertal and 40 early modern human remains. The biomolecular preservation of four Neandertals and of five early modern humans was good enough to suggest the preservation of DNA. All four Neandertals yielded mtDNA sequences similar to those previously determined from Neandertal individuals, whereas none of the five early modern humans contained such mtDNA sequences. In combination with current mtDNA data, this excludes any large genetic contribution by Neandertals to early modern humans, but does not rule out the possibility of a smaller contribution. Analysis of mitochondrial DNA from four Neandertal fossils and five "modern human" contemporaries excludes any large genetic contribution of Neandertals to the gene pool of modern humans |
| Databáze: | OpenAIRE |
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