Psychoneuropharmacological activities and chemical composition of essential oil of fresh fruits of Piper guineense (Piperaceae) in mice
| Autor: | Moses A. Akanmu, Akeeb Alabi, Adebola Omowumi Oyedeji, Omotola Aanuoluwa Olayera, Idris Ajayi Oyemitan, Luqman Adewale Abass, Christianah A. Elusiyan |
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| Rok vydání: | 2014 |
| Předmět: |
Central Nervous System
Male medicine.drug_class medicine.medical_treatment Acyclic Monoterpenes Pharmacology Catalepsy Motor Activity law.invention Body Temperature chemistry.chemical_compound Mice Linalool law Drug Discovery Cyclohexenes medicine Oils Volatile Animals Hypnotics and Sedatives Piper guineense Essential oil Bicyclic Monoterpenes Limonene biology Plant Extracts Terpenes Muscle relaxant Piperaceae biology.organism_classification medicine.disease Monocyclic Sesquiterpenes Anticonvulsant chemistry Anti-Anxiety Agents Fruit Ethnopharmacology Monoterpenes Anticonvulsants Female Sleep Piper Sesquiterpenes Phytotherapy |
| Zdroj: | Journal of ethnopharmacology. 166 |
| ISSN: | 1872-7573 |
| Popis: | Ethnopharmacological relevance Piper guineense Schum & Thonn (Piperaceae) is a medicinal plant used in the Southern States of Nigeria to treat fever, mental disorders and febrile convulsions. Aims of the study This study aims at determining the chemical composition and the central nervous system (CNS) activities of the essential oil obtained from the plant׳s fresh fruits in order to rationalize its folkloric use. Materials and methods Essential oil of P. guineense (EOPG) obtained by hydrodistillation was analysed by GC/MS. EOPG (50–200 mg/kg, i.p.) was evaluated for behavioural, hypothermic, sedative, muscle relaxant, anti-psychotic and anticonvulsant activities using standard procedures. Results and discussion Analysis of the oil reveals 44 compounds of which 30 compounds constituting 84.7% were identified. The oil was characterized by sesquiterpenoids (64.4%) while only four monoterpeneoids (21.3%) were found present in the oil. Major compounds identified were β-sesquiphellandrene (20.9%), linalool (6.1%), limonene (5.8%), Z-β-bisabolene (5.4%) and α-pinene (5.3%). The EOPG (50–200 mg/kg, i.p.) caused significant ( p F (4,20) =43}, locomotor { F (4,20) =22} activity and decreased head dips in hole board { F (4,20) =7} indicating CNS depressant effect; decreased rectal temperature { F (4,20) =7–16}, signifying hypothermic activity; decreased ketamine-induced sleep latency { F (4,20) =7.8} and prolonged total sleeping time { F (4,20) =8.8}, indicating sedative effect; reduced muscular tone on the hind-limb grip test { F (4,20) =22}, inclined board { F (4,20) =4–49} and rota rod { F (4,20) =13–106}, implying muscle relaxant activity; induced catalepsy { F (4,20) =47–136}, inhibited apomorphine-induced climbing behaviour { F (4,20) =9} and inhibited apomorphine-induced locomotor { F (4,20) =16}, suggesting anti-psychotic effect; and protected mice against pentylenetetrazole-induced convulsions, indicating anticonvulsant potential. Conclusion The most abundant component of the fresh fruits essential oil of P. guineense was β-sesquiphellandrene (20.9%); and the oil possesses CNS depressant, hypothermic, sedative, muscle relaxant, antipsychotic and anticonvulsant activities, thus providing scientific basis for its ethnomedicinal applications. |
| Databáze: | OpenAIRE |
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