Serological diagnosis of hepatitis B and delta virus (HBV/HDV) coinfection
| Autor: | E. Chiaberge, Maria Luisa Soranzo, Spezia C, Enrica Pessione, Ferruccio Bonino, C Lavarini, Salassa B, Maurizia Rossana Brunetto, Floriano Rosina, Antonina Smedile, Enrica Daziano, C. Bramato |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Hepatitis B virus viruses Immunoblotting Radioimmunoassay medicine.disease_cause Virus Humans Medicine Serologic Tests Hepatitis Hepatitis B Surface Antigens Hepatology biology business.industry Nucleic Acid Hybridization virus diseases RNA Probes Hepatitis B medicine.disease Hepatitis D Virology Immunoglobulin M biology.protein Coinfection RNA Viral Female Viral disease Hepatitis Delta Virus business |
| Zdroj: | Journal of Hepatology. 12:10-13 |
| ISSN: | 0168-8278 |
| Popis: | Diagnosis of acute hepatitis B virus/hepatitis delta virus (HBV/HDV) coinfection is currently based on detection of anti-HD, however this antibody may be undetectable during the acute phase of hepatitis. To evaluate the entity of misdiagnosis of HBV/HDV coinfection in acute HBsAg-anti-HBc IgM positive hepatitis we examined sera from 245 consecutive patients obtained at admission and day 30, 60, 120, 210 and 400 of their follow-up. Anti-HD was detected in the serum of 26 out of 245 patients (10.6%). In 15% of cases it was present at admission, while in 92% it was found after 30 days. The combined detection of HDV-RNA, HDAg and IgM anti-HD in acute phase sera allowed a correct etiologic diagnosis in 69% of the cases. These findings suggest that the prevalence of HBV/HDV coinfection is underestimated when anti-HD is the only marker to be detected during the acute phase of disease. A correct etiologic diagnosis can only be made by testing acute phase sera for all the available markers of HDV. However, the best cost-effective procedure is to test any patient with HBV markers at presentation for anti-HD, 30-40 days after the onset of symptoms. |
| Databáze: | OpenAIRE |
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