Microglial Content-Dependent Inhibitory Effects of Calcitonin Gene-Related Peptide (CGRP) on Murine Retroviral Infection of Glial Cells

Autor: Ling Cao, Eliza Grlickova-Duzevik, Holly Beaulac, Jennifer T. Malon, James Vaughn, Tyler R. Vunk
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
peripheral neuropathy
glia
animal diseases
Cell Count
retroviral infection
Viral Plaque Assay
LP-BM5
Mice
0302 clinical medicine
Immunology and Allergy
Cells
Cultured
0303 health sciences
virus diseases
3. Good health
Up-Regulation
medicine.anatomical_structure
Neurology
Spinal Cord
Cytokines
Neuroglia
medicine.medical_specialty
Calcitonin Gene-Related Peptide
Immunology
Calcitonin gene-related peptide
Inhibitory postsynaptic potential
Article
03 medical and health sciences
In vivo
Internal medicine
medicine
Animals
030304 developmental biology
Analysis of Variance
business.industry
Calcitonin gene-related peptide (CGRP)
medicine.disease
Spinal cord
murine acquired immunodeficiency syndrome (MAIDS)
In vitro
Mice
Inbred C57BL
Lumbar Spinal Cord
Disease Models
Animal
Endocrinology
Peripheral neuropathy
Retroviridae
nervous system
Gene Expression Regulation
Calcitonin
Neurology (clinical)
business
030217 neurology & neurosurgery
Retroviridae Infections
Zdroj: Journal of neuroimmunology
ISSN: 1872-8421
0165-5728
Popis: C57BL/6 (B6) mice develop peripheral neuropathy post-LP-BM5 infection, a murine model of HIV-1 infection, along with the up-regulation of select spinal cord cytokines. We investigated if calcitonin gene-related peptide (CGRP) contributed to the development of peripheral neuropathy by stimulating glial responses. An increased expression of lumbar spinal cord CGRP was observed in vivo, post-LP-BM5 infection. Consequently, in vitro CGRP co-treatments led to a microglial content-dependent attenuation of viral loads in spinal cord mixed glia infected with selected doses of LP-BM5. This inhibition was neither caused by the loss of glia nor induced via the direct inhibition of LP-BM5 by CGRP.
Databáze: OpenAIRE
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