Evaluation of a commercial DIR platform for contour propagation in prostate cancer patients treated with IMRT/VMAT

Autor: Xianming Tan, J Hammers, Ronald C. Chen, Daniel P. Lindsay, Sara Pirozzi, Orit Kaidar-Person, Panayiotis Mavroidis, Shiva K. Das
Rok vydání: 2020
Předmět:
Male
Linear mixed effect model
Jaccard index
genetic structures
Image registration
VMAT
Pattern Recognition
Automated
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Similarity (network science)
Image Processing
Computer-Assisted
Humans
Radiation Oncology Physics
Radiology
Nuclear Medicine and imaging
IMRT
deformable image registration
Instrumentation
Cone beam ct
Image-guided radiation therapy
Mathematics
Radiation
business.industry
Radiotherapy Planning
Computer-Assisted
cone beam CT
Prostatic Neoplasms
Reproducibility of Results
Cone-Beam Computed Tomography
prostate cancer
Distance to agreement
Hausdorff distance
030220 oncology & carcinogenesis
Linear Models
Radiographic Image Interpretation
Computer-Assisted
Radiotherapy
Intensity-Modulated
Factor Analysis
Statistical
Tomography
X-Ray Computed
Nuclear medicine
business
Algorithms
Software
Radiotherapy
Image-Guided
Zdroj: Journal of Applied Clinical Medical Physics
ISSN: 1526-9914
Popis: Purpose To assess the performance and limitations of contour propagation with three commercial deformable image registration (DIR) algorithms using fractional scans of CT‐on‐rails (CTOR) and Cone Beam CT (CBCT) in image guided prostate therapy patients treated with IMRT/VMAT. Methods Twenty prostate cancer patients treated with IMRT/VMAT were selected for analysis. A total of 453 fractions across those patients were analyzed. Image data were imported into MIM (MIM Software, Inc., Cleveland, OH) and three DIR algorithms (DIR Profile, normalized intensity‐based (NIB) and shadowed NIB DIR algorithms) were applied to deformably register each fraction with the planning CT. Manually drawn contours of bladder and rectum were utilized for comparison against the DIR propagated contours in each fraction. Four metrics were utilized in the evaluation of contour similarity, the Hausdorff Distance (HD), Mean Distance to Agreement (MDA), Dice Similarity Coefficient (DSC), and Jaccard indices. A subfactor analysis was performed per modality (CTOR vs. CBCT) and time (fraction). Point estimates and 95% confidence intervals were assessed via a Linear Mixed Effect model for the contour similarity metrics. Results No statistically significant differences were observed between the DIR Profile and NIB algorithms. However, statistically significant differences were observed between the shadowed NIB and NIB algorithms for some of the DIR evaluation metrics. The Hausdorff Distance calculation showed the NIB propagated contours vs. shadowed NIB propagated contours against the manual contours were 14.82 mm vs. 8.34 mm for bladder and 15.87 mm vs. 11 mm for rectum, respectively. Similarly, the Mean Distance to Agreement calculation comparing the NIB propagated contours vs. shadowed NIB propagated contours against the manual contours were 2.43 mm vs. 0.98 mm for bladder and 2.57 mm vs. 1.00 mm for rectum, respectively. The Dice Similarity Coefficients comparing the NIB propagated contours and shadowed NIB propagated contours against the manual contours were 0.844 against 0.936 for bladder and 0.772 against 0.907 for rectum, respectively. The Jaccard indices comparing the NIB propagated contours and shadowed NIB propagated contours against the manual contours were 0.749 against 0.884 for bladder and 0.637 against 0.831 for rectum, respectively. The shadowed NIB DIR, which showed the closest agreement with the manual contours performed significantly better than the DIR Profile in all the comparisons. The OAR with the greatest agreement varied substantially across patients and image guided radiation therapy (IGRT) modality. Intra‐patient variability of contour metric evaluation was insignificant across all the DIR algorithms. Statistical significance at α = 0.05 was observed for manual vs. deformably propagated contours for bladder for all the metrics except Hausdorff Distance (P = 0.01 for MDA, P = 0.02 for DSC, P = 0.01 for Jaccard), whereas the corresponding values for rectum were: P = 0.03 for HD, P = 0.01 for MDA, P
Databáze: OpenAIRE
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