The relationship between interleukin-6 and functional connectivity in methamphetamine users
| Autor: | William F. Hoffman, Milky Kohno, Jennifer M. Loftis, Laura E. Dennis, Marilyn Huckans, Holly McCready |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine media_common.quotation_subject Amphetamine-Related Disorders Article Methamphetamine 03 medical and health sciences 0302 clinical medicine Neural Pathways Humans Medicine Interleukin 6 media_common Inflammation Brain Mapping medicine.diagnostic_test biology Interleukin-6 business.industry General Neuroscience Functional connectivity Addiction Dopaminergic Brain Control subjects Magnetic Resonance Imaging 030104 developmental biology biology.protein Female business Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuroscience Letters. 677:49-54 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2018.04.037 |
| Popis: | Methamphetamine (MA) causes an increase in pro-inflammatory cytokines in animal models and in humans. Resulting activation of microglia and neuro-inflammation could, via effects on reward networks, mediate behavioral characteristics of addiction. We examined the relationship between interleukin-6 (IL-6) and corticolimbic and striatolimbic resting-state functional connectivity (RSFC). Thirty adults diagnosed with MA dependence and 20 control subjects underwent a resting-state functional magnetic resonance imaging (fMRI) scan and gave a blood sample for determination of plasma IL-6 levels. Seed-based RSFC analyses were performed to examine the interactive effect of group and IL-6 on ventral striatal and prefrontal connectivity. Within the MA group, IL-6 levels were positively related to striatolimbic RSFC but negatively related to corticostriatal RSFC. Our findings with IL-6 support the idea that inflammation may at least partly mediate the link among MA use disorder, RSFC, and behavior, possibly via effects on mesolimbic and mesocortical dopaminergic systems. |
| Databáze: | OpenAIRE |
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