Aortic Intima Media Thickness is an Early Marker of Atherosclerosis in Children with Type 1 Diabetes Mellitus
| Autor: | Roger Gent, Craig Hirte, Jennifer Harrington, Jennifer J Couper, Alexia S Peña |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Carotid Artery Common Matched-Pair Analysis chemistry.chemical_compound Risk Factors Internal medicine Diabetes mellitus medicine Humans Aorta Abdominal Child Ultrasonography Glycated Hemoglobin Type 1 diabetes biology business.industry Vascular disease C-reactive protein Age Factors Case-control study Cholesterol LDL Atherosclerosis medicine.disease Diabetes Mellitus Type 1 Early Diagnosis Endocrinology Intima-media thickness chemistry Case-Control Studies Low-density lipoprotein Metabolic control analysis Multivariate Analysis Pediatrics Perinatology and Child Health Linear Models cardiovascular system Cardiology biology.protein Female Tunica Intima business Biomarkers |
| Zdroj: | The Journal of Pediatrics. 156:237-241 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/j.jpeds.2009.08.036 |
| Popis: | To compare aortic intima media thickness (aIMT) to carotid intima media thickness (cIMT) as a marker of early atherosclerosis in children with type 1 diabetes mellitus and to examine the associations of aIMT to known cardiovascular risk factors.66 children with type 1 diabetes mellitus (age, 14.1 +/- 2.5 years; 37 male) and 32 healthy control subjects (age, 14.2 +/- 3 years; 15 male) underwent assessment of vascular structure (cIMT and aIMT) and vascular function (flow mediated dilatation [FMD] and glyceryl trinitrate induced dilatation [GTN]). Fasting blood tests were taken to measure levels of hemoglobin A1c, high sensitive C reactive protein, total homocyst(e)ine, serum folate, red cell folate, and lipids.aIMT, but not cIMT, was significantly greater in the children with type 1 diabetes mellitus than in control subjects (P.001). In children with type 1 diabetes mellitus, aIMT correlated with glycosylated hemoglobin (r = 0.31, P = .01) and was independently associated with age (beta = 0.38, P = .001) and low-density lipoprotein cholesterol level (beta = 0.38, P = .001). Vascular function (GTN) was worse in children with type 1 diabetes mellitus who had an aIMT95th percentile, as defined with the control subjects.aIMT is an earlier marker than cIMT of preclinical atherosclerosis in children with type 1 diabetes mellitus and relates to known cardiovascular risk factors and metabolic control. |
| Databáze: | OpenAIRE |
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