Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials

Autor: Tilakavati Karupaiah, Soelaiman Ima-Nirwana, Shing Cheng Tan, Hui-Ci Tiong, Kok-Yong Chin, Abdul Halim Abdul Gafor, Sok Kuan Wong, Ban-Hock Khor
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
medicine.medical_treatment
Anti-Inflammatory Agents
Organic chemistry
medicine.disease_cause
Gastroenterology
Biochemistry
Antioxidants
law.invention
chemistry.chemical_compound
0302 clinical medicine
Mathematical and Statistical Techniques
Randomized controlled trial
law
Medicine and Health Sciences
Vitamin E
Immune Response
Randomized Controlled Trials as Topic
Multidisciplinary
Tocotrienols
Statistics
Vitamins
Metaanalysis
Research Assessment
Middle Aged
Malondialdehyde
C-Reactive Proteins
Chemistry
Meta-analysis
Physical Sciences
Medicine
Female
Research Article
Adult
medicine.medical_specialty
Dose
Systematic Reviews
Science
Immunology
030209 endocrinology & metabolism
Subgroup analysis
Research and Analysis Methods
03 medical and health sciences
Chemical compounds
Signs and Symptoms
Internal medicine
Organic compounds
medicine
Humans
Statistical Methods
Inflammation
030109 nutrition & dietetics
business.industry
Biology and Life Sciences
Proteins
Cell Biology
Confidence interval
Oxidative Stress
chemistry
Dietary Supplements
Clinical Medicine
business
Oxidative stress
Mathematics
Biomarkers
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0255205 (2021)
ISSN: 1932-6203
Popis: Studies investigating the effects of tocotrienols on inflammation and oxidative stress have yielded inconsistent results. This systematic review and meta-analysis aimed to evaluate the effects of tocotrienols supplementation on inflammatory and oxidative stress biomarkers. We searched PubMed, Scopus, and Cochrane Central Register of Controlled Trials from inception until 13 July 2020 to identify randomized controlled trials supplementing tocotrienols and reporting circulating inflammatory or oxidative stress outcomes. Weighted mean difference (WMD) and corresponding 95% confidence interval (CI) were determined by pooling eligible studies. Nineteen studies were included for qualitative analysis, and 13 studies were included for the meta-analyses. A significant reduction in C-reactive protein levels (WMD: −0.52 mg/L, 95% CI: −0.73, −0.32, p < 0.001) following tocotrienols supplementation was observed, but this finding was attributed to a single study using δ-tocotrienols, not mixed tocotrienols. There were no effects on interleukin-6 (WMD: 0.03 pg/mL, 95% CI: −1.51, 1.58, p = 0.966), tumor necrosis factor-alpha (WMD: −0.28 pg/mL, 95% CI: −1.24, 0.68, p = 0.571), and malondialdehyde (WMD: −0.42 μmol/L, 95% CI: −1.05, 0.21, p = 0.189). A subgroup analysis suggested that tocotrienols at 400 mg/day might reduce malondialdehyde levels (WMD: −0.90 μmol/L, 95% CI: −1.20, −0.59, p < 0.001). Future well-designed studies are warranted to confirm the effects of tocotrienols on inflammatory and oxidative stress biomarkers, particularly on different types and dosages of supplementation. PROSPERO registration number: CRD42020198241.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje