Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials
Autor: | Tilakavati Karupaiah, Soelaiman Ima-Nirwana, Shing Cheng Tan, Hui-Ci Tiong, Kok-Yong Chin, Abdul Halim Abdul Gafor, Sok Kuan Wong, Ban-Hock Khor |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Male medicine.medical_treatment Anti-Inflammatory Agents Organic chemistry medicine.disease_cause Gastroenterology Biochemistry Antioxidants law.invention chemistry.chemical_compound 0302 clinical medicine Mathematical and Statistical Techniques Randomized controlled trial law Medicine and Health Sciences Vitamin E Immune Response Randomized Controlled Trials as Topic Multidisciplinary Tocotrienols Statistics Vitamins Metaanalysis Research Assessment Middle Aged Malondialdehyde C-Reactive Proteins Chemistry Meta-analysis Physical Sciences Medicine Female Research Article Adult medicine.medical_specialty Dose Systematic Reviews Science Immunology 030209 endocrinology & metabolism Subgroup analysis Research and Analysis Methods 03 medical and health sciences Chemical compounds Signs and Symptoms Internal medicine Organic compounds medicine Humans Statistical Methods Inflammation 030109 nutrition & dietetics business.industry Biology and Life Sciences Proteins Cell Biology Confidence interval Oxidative Stress chemistry Dietary Supplements Clinical Medicine business Oxidative stress Mathematics Biomarkers |
Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 7, p e0255205 (2021) |
ISSN: | 1932-6203 |
Popis: | Studies investigating the effects of tocotrienols on inflammation and oxidative stress have yielded inconsistent results. This systematic review and meta-analysis aimed to evaluate the effects of tocotrienols supplementation on inflammatory and oxidative stress biomarkers. We searched PubMed, Scopus, and Cochrane Central Register of Controlled Trials from inception until 13 July 2020 to identify randomized controlled trials supplementing tocotrienols and reporting circulating inflammatory or oxidative stress outcomes. Weighted mean difference (WMD) and corresponding 95% confidence interval (CI) were determined by pooling eligible studies. Nineteen studies were included for qualitative analysis, and 13 studies were included for the meta-analyses. A significant reduction in C-reactive protein levels (WMD: −0.52 mg/L, 95% CI: −0.73, −0.32, p < 0.001) following tocotrienols supplementation was observed, but this finding was attributed to a single study using δ-tocotrienols, not mixed tocotrienols. There were no effects on interleukin-6 (WMD: 0.03 pg/mL, 95% CI: −1.51, 1.58, p = 0.966), tumor necrosis factor-alpha (WMD: −0.28 pg/mL, 95% CI: −1.24, 0.68, p = 0.571), and malondialdehyde (WMD: −0.42 μmol/L, 95% CI: −1.05, 0.21, p = 0.189). A subgroup analysis suggested that tocotrienols at 400 mg/day might reduce malondialdehyde levels (WMD: −0.90 μmol/L, 95% CI: −1.20, −0.59, p < 0.001). Future well-designed studies are warranted to confirm the effects of tocotrienols on inflammatory and oxidative stress biomarkers, particularly on different types and dosages of supplementation. PROSPERO registration number: CRD42020198241. |
Databáze: | OpenAIRE |
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