Association of chemokine (CXC motif) receptor 4 expression with lymphovascular invasion and lymph node metastasis of invasive breast cancer

Autor:	Lidya, Mamonto, Berti J, Nelwan, Ni Ketut, Sungowati, Upik A, Miskad, Muh Husni, Cangara, Andi Alfian, Zainuddin
Rok vydání:	2023
Předmět:	Cancer Research Oncology General Medicine
Zdroj:	Breast Disease. 41:447-453
ISSN:	1558-1551 0888-6008
Popis:	BACKGROUND: The histological tumor grade influences the prognosis of breast cancer. In metastatic breast cancer, stromal cells produce chemokine (CXC motif) ligand 12 or stromal cell-derived factor-1 as a chemoattractant, which binds to chemokine (CXC motif) receptor 4 (CXCR4) expressed by breast cancer cells. OBJECTIVE: This study aimed to determine the expression of CXCR4 in invasive breast cancer in relation to lymphovascular invasion (LVI) and lymph node metastasis. METHODS: This observational study retrospectively investigated a paraffin block archived sample diagnosed with invasive breast cancer. The results of immunohistochemical staining with CXCR4 antibody and expression analysis were evaluated using light microscopy. The data were statistically analyzed using the chi-square test and presented in a table using SPSS version 18. P-values of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e59214676cad65e35a37d0842278152 https://doi.org/10.3233/bd-229003 Zobrazit plný text záznamu