High Throughput Synthesis of Extended Pyrazolo[3,4-d]dihydropyrimidines

Autor:	Alexander Shivanyuk, Dmitry S. Granat, Andrey S. Plaskon, Sergey V. Ryabukhin, Andrey A. Tolmachev, Yulian M. Volovenko
Rok vydání:	2012
Předmět:	Molecular Structure Chemistry Condensation General Chemistry General Medicine law.invention Pyrimidines law Yield (chemistry) Electrophile Combinatorial Chemistry Techniques Pyrazoles Molecule Organic chemistry Crystallization
Zdroj:	ACS Combinatorial Science. 14:465-470
ISSN:	2156-8944 2156-8952
DOI:	10.1021/co300063x
Popis:	Thirteen 5-hetarylaminopyrazoles were synthesized in 62-93% yield through the arylation of 1-isopropyl- and 1-phenyl-5-aminopyrazoles with electrophilic hetarylhalides under optimized conditions. Condensation of 5-hetarylaminopyrazoles with carbonyl compounds facilitated by AcOH or Me(3)SiCl furnished 23 pyrazolo[3,4-d]dihydropyrimidines in 69-86% yield. The target compounds were isolated through simple crystallization. The scope and limitation of the method are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e58c0e574235ebe1fef8a9297a59135 https://doi.org/10.1021/co300063x Zobrazit plný text záznamu