Local treatment of triple-negative breast cancer
Autor: | Philip Poortmans, Isabel T. Rubio, M. Machiels, Orit Kaidar-Person |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Oncology Extensive Radiation Cancer Research medicine.medical_specialty medicine.medical_treatment Triple Negative Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Breast-conserving surgery medicine Humans Radical surgery Triple-negative breast cancer Chemotherapy business.industry medicine.disease Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Quality of Life Female Human medicine Neoplasm Recurrence Local business Mastectomy |
Zdroj: | The cancer journal |
ISSN: | 1528-9117 |
Popis: | Triple-negative breast cancer, compared with other molecular subtypes, poses particular challenges for optimizing the timing and the extent of locoregional treatments. In the past, the combination of increased rates of both locoregional and distant recurrences led to a preference of radical surgery and extensive radiation therapy; however, since the introduction of more effective chemotherapy, a sharp de-escalation in the extent of locoregional treatments followed. Current evidence confirms that less aggressive surgery in combination with tailored radiation therapy offers improved oncological outcomes combined with better quality of life. However, further research is required to optimize locoregional treatments, considering the significant heterogeneity in biological behavior and tumor response to systemic treatments. |
Databáze: | OpenAIRE |
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