Latent Transforming Growth Factor β Binding Protein 2 (LTBP2) as a Novel Biomarker for the Diagnosis and Prognosis of Pancreatic Carcinoma
| Autor: | Yajun Wei, Lu Zhang, Jingen Pan, Gang Wang, Cheng Wang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Pancreatic disease Kaplan-Meier Estimate Adenocarcinoma Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Lab/In Vitro Research Internal medicine Diagnosis medicine Carcinoma Biomarkers Tumor Humans Aged business.industry Area under the curve Cancer General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Pancreatic Neoplasms Latent TGF-beta binding protein 030104 developmental biology Latent TGF-beta Binding Proteins ROC Curve 030220 oncology & carcinogenesis Multivariate Analysis Biomarker (medicine) Female business Transforming growth factor Carcinoma Pancreatic Ductal |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| Popis: | BACKGROUND Latent transforming growth factor b binding protein 2 (LTBP2) is proven to be associated with ECM and involved in the advancement of several kinds of cancer. The present study evaluated the diagnosis and prognosis of pancreatic carcinoma (PC) using LTBP2 as a biomarker. MATERIAL AND METHODS Protein levels of LTBP2 were evaluated in 111 pairs of pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent nontumor tissues via immunohistochemistry. ELISA method was used to quantify the serum concentration of LTBP2. The subjects in this study included 141 PDAC patients, 20 patients with benign pancreatic disease, and 20 healthy volunteers. RESULTS IHC results showed that LTBP2 levels were significantly elevated in the PDAC tissues as compared with the adjacent nontumor tissues (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|