A review of sex-specific benefits and risks of antithrombotic therapy in acute coronary syndrome
| Autor: | William T. Wang, Tracy Y. Wang, Stefan James |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Alternative medicine Medication adherence Sex-specific differences Hemorrhage 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Fibrinolytic Agents Risk Factors Antithrombotic Medicine Humans Cardiac and Cardiovascular Systems 030212 general & internal medicine Dosing Thrombus Acute Coronary Syndrome Intensive care medicine Antithrombotic therapy Sex Characteristics Kardiologi business.industry medicine.disease Sex specific Treatment Outcome Female Cardiology and Cardiovascular Medicine business Fibrinolytic agent Forecasting |
| Popis: | Over the past decade, more men than women have shown improved outcomes from antithrombotic therapies after acute coronary syndrome (ACS), which raises the question of whether there are sex-specific differences in treatment patterns and response to therapy. Differences in presenting clinical characteristics, pathophysiologic profile, and disparities in treatment may contribute to this outcomes discrepancy. Analyses of large trials and registry data suggest that male and female ACS patients experience similar benefits from antithrombotic therapy without significant difference in treatment utilization rates, yet women are consistently at higher risk of bleeding than men. Bleeding may result in antithrombotic treatment disruption, which increases the risk of long-term thrombotic events. Additionally, female ACS patients are more likely to receive suboptimal medication dosing and have lower rates of long-term medication adherence. These differences have significant clinical implications for women, indicating the need for strategies that will optimize initial treatment and long-term management attuned to these recognized sex-specific gaps. |
| Databáze: | OpenAIRE |
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