Multiple sclerosis: individualized disease susceptibility and therapy response
| Autor: | Milos Markovic, Vera Pravica, Marija Mostarica-Stojkovic, Dusan Popadic, Jelena Drulovic, Maja Cupic, Emina Savic |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Clinical Biochemistry Disease Polymorphism Single Nucleotide Disease course 03 medical and health sciences Disease susceptibility 0302 clinical medicine HLA Antigens Drug Discovery medicine Humans Precision Medicine Intensive care medicine 030304 developmental biology 0303 health sciences business.industry Multiple sclerosis Biochemistry (medical) Prognosis medicine.disease Precision medicine 3. Good health Therapy response Physical therapy Disease Susceptibility Personalized medicine business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Biomarkers in Medicine. 7:59-71 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm.12.113 |
| Popis: | Multiple sclerosis (MS) is a heterogeneous disease in which diverse genetic, pathological and clinical backgrounds lead to variable therapy response. Accordingly, MS care should be tailored to address disease traits unique to each person. At the core of personalized management is the emergence of new knowledge, enabling optimized treatment and disease-modifying therapies. This overview analyzes the promise of genetic and nongenetic biomarkers in advancing decision-making algorithms to assist diagnosis or in predicting the disease course and therapy response in any given MS patient. |
| Databáze: | OpenAIRE |
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