Primary sinonasal malignant melanoma with systemic metastasis in a non-gray horse
| Autor: | Takashi Hatazoe, Haruka Seo, Hitoshi Hatai, Shingo Ishikawa, Teruaki Tozaki, Noriaki Miyoshi, Kazuhiro Misumi, Seiji Hobo |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty 040301 veterinary sciences Nose Neoplasms Metastasis 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Left maxilla medicine Animals Horses Neoplasm Metastasis Melanoma General Veterinary business.industry Mucosal melanoma 04 agricultural and veterinary sciences medicine.disease Left maxillary sinus Systemic metastasis 030220 oncology & carcinogenesis Horse Diseases Brief Reports Fenestration business |
| Zdroj: | J Vet Diagn Invest |
| ISSN: | 1943-4936 1040-6387 |
| Popis: | A 27-y-old Anglo-Arabian gelding with bay coat color was presented with a swelling of the left maxillary region. Fenestration on the left maxilla revealed that the left maxillary sinus was filled with black-red tissue. A portion of the tissue was excised and diagnosed histologically as malignant melanoma. Genotyping of the STX17 gene for gray coat color revealed that the horse did not have the “gray” factor. The horse was euthanized ~3 mo after first presentation. During autopsy, a black-to-gray mass extended from the left nasal cavity to the surrounding paranasal sinus and invaded the hard palate, cribriform plate, and the cranial portion of the left olfactory bulb. Moreover, identical black nodules were present in lymph nodes from the mandible to the larynx, and in the spleen, liver, kidney, and adrenal glands. However, masses were not found in the skin, perineal region, or pelvic cavity. All of the black-to-gray nodules were malignant melanomas that were histologically identical to the initial biopsy; tumor emboli were also found in the kidney. Sinonasal mucosal melanoma is a rare disease in horses. |
| Databáze: | OpenAIRE |
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