Lipid-based submicron capsules as a strategy to include high concentrations of a hydrophobic lightening agent in a hydrogel

Autor: Thomas Perrier, Florent Yvergnaux, Igor Chourpa, Martin Soucé, Xavier Perse, Emilie Munnier, Francis Vial, Hoang Truc Phuong Nguyen
Přispěvatelé: Nanomédicaments et Nanosondes, EA 6295 (NMNS), Université de Tours (UT), Département de pharmacochimie moléculaire (DPM ), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Spincontrol France, Tours, France, Carlina Technologies, Angers, France, Bioeurope Groupe Solabia, Université de Tours
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Quality Control
Aging
spectroscopy
Skin Lightening Preparations
Pharmaceutical Science
Nanotechnology
02 engineering and technology
Dermatology
Laboratory scale
030226 pharmacology & pharmacy
High-performance liquid chromatography
03 medical and health sciences
0302 clinical medicine
Colloid and Surface Chemistry
Rheology
Dynamic light scattering
[CHIM.ANAL]Chemical Sciences/Analytical chemistry
Drug Discovery
Zeta potential
skin lightening
Chromatography
High Pressure Liquid
Active ingredient
High concentration
formulation/stability
Chemistry
Nanoencapsulation
021001 nanoscience & nanotechnology
Lipids
Formulation stability
[SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology
Chemical engineering
Chemistry (miscellaneous)
chemical analysis
0210 nano-technology
Hydrophobic and Hydrophilic Interactions
Zdroj: International Journal of Cosmetic Science
International Journal of Cosmetic Science, Wiley, 2017, 39 (4), pp.450-456. ⟨10.1111/ics.12397⟩
ISSN: 0142-5463
DOI: 10.1111/ics.12397⟩
Popis: International audience; OBJECTIVE: The present study aims at increasing the concentration of a hydrophobic lightening agent, Omegalight® , in a hydrophilic cosmetic product by means of encapsulation in lipid-based submicron capsules. The core of these capsules is entirely made of the commercial lightening agent.METHODS: Lipid-based encapsulation systems (LNC) were prepared by the PIT method. Their physicochemical properties were followed over 6 months by dynamic light scattering and zeta potential measurements, and in parallel the potential degradation of the active ingredient was monitored by HPLC. The stability of the capsules in a cosmetic gel was studied by spectrofluorimetry and rheology measurements. Sensory analysis was used to determine the influence of the presence of capsules in the gel on the consumer's experience.RESULTS: LNC encapsulating Omegalight® were prepared on a laboratory scale and then on a semi-pilot scale. Their hydrodynamic diameters are around 230 nm. The concentration of Omegalight® in the capsules reaches about 84% w/w, which corresponds to 42% of active ingredient. LNC can be dispersed without degradation at concentrations of up to 20% w/w in a hydrogel without modification of the physicochemical or sensory properties of the gel.CONCLUSION: Lipid-based capsules (LNC), an encapsulation system useful for the epidermal delivery of hydrophobic compounds, were adapted to the encapsulation of a commercial lightening agent. The encapsulation permits the dispersion in a stable manner of a very high concentration of a hydrophobic active molecule in a hydrogel while maintaining the physicochemical and sensory properties of the gel. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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