Immunohistochemical Expression of Cyclo-oxygenase 2 and Liver X Receptor-α in Acne Vulgaris
| Autor: | Noha Nour El Din El Kady, Hend Farag Abu Dawy, Shawky Mahmoud El Farargy, Ola Ahmed Bakry |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Dermatology Section Clinical Biochemistry lcsh:Medicine Inflammation Gastroenterology Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Papulopustular Internal medicine medicine Liver X receptor Acne lipogenesis business.industry lcsh:R food and beverages Lipid metabolism General Medicine medicine.disease inflammation pilosebaceous unit Personal computer immunohistochemistry Immunohistochemistry medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 11, Iss 9, Pp WC01-WC07 (2017) |
| Popis: | Introduction: Acne Vulgaris (AV) is a common inflammatory disease of pilosebaceous units. Liver X Receptor-α (LXR-α) is a ligand activated transcription factor. It controls transcription of genes involved in lipid and fatty acid synthesis. Cyclooxygenase 2 (COX2) is a rate limiting enzyme in prostaglandin synthesis. It plays important role in inflammation. Aim: To evaluate the immunohistochemical expression of LXR-α and COX2 in acne vulgaris skin biopsies to explore their possible pathogenic role in this disease. Materials and Methods: Sixty five subjects were included (45 cases with AV and 20 age and gender-matched healthy controls). Skin biopsies were taken from lesional and perilesional skin of cases and from site-matched areas of control subjects. The evaluation of LXR-α and COX2 was done using immunohistochemical technique. Data were collected, tabulated and statistically analysed using a personal computer with “(SPSS) version 11” program. Chi-square test was used to study the association between qualitative variables. Mann– Whitney test was used for comparison between quantitative variables. Student’s t-test was used for comparison between two groups having quantitative variables. Spearman’s coefficient was used to study the correlation between two different variables. Differences were considered statistically significant with p |
| Databáze: | OpenAIRE |
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