High definition transcranial direct current stimulation modulates abnormal neurophysiological activity in post-stroke aphasia
| Autor: | Alexander Francois-Nienaber, Gayatri Sivaratnam, Sumiti Nayar, Jed A. Meltzer, Sabrina E.M. Armstrong, Maryam Yossofzai, Regina Jokel, Selina Teti, Priyanka P. Shah-Basak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment lcsh:Medicine Audiology Transcranial Direct Current Stimulation Severity of Illness Index Article 050105 experimental psychology Lesion 03 medical and health sciences 0302 clinical medicine Aphasia medicine Humans 0501 psychology and cognitive sciences lcsh:Science Stroke Pathological Aged Language Aged 80 and over Multidisciplinary medicine.diagnostic_test Transcranial direct-current stimulation business.industry lcsh:R 05 social sciences Stroke Rehabilitation Magnetoencephalography Middle Aged Neurophysiology medicine.disease Diseases of the nervous system Female lcsh:Q medicine.symptom business Stroke recovery 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-76533-0 |
| Popis: | Recent findings indicate that measures derived from resting-state magnetoencephalography (rsMEG) are sensitive to cortical dysfunction in post-stroke aphasia. Spectral power and multiscale entropy (MSE) measures show that left-hemispheric areas surrounding the stroke lesion (perilesional) exhibit pathological oscillatory slowing and alterations in signal complexity. In the current study, we tested whether individually-targeted high-definition transcranial direct current stimulation (HD-tDCS) can reduce MEG abnormalities and transiently improve language performance. In eleven chronic aphasia survivors, we devised a method to localize perilesional areas exhibiting peak MSE abnormalities, and subsequently targeted these areas with excitatory/anodal-tDCS, or targeted the contralateral homolog areas with inhibitory/cathodal-tDCS, based on prominent theories of stroke recovery. Pathological MEG slowing in these patients was correlated with aphasia severity. Sentence/phrase repetition accuracy was assessed before and after tDCS. A delayed word reading task was administered inside MEG to assess tDCS-induced neurophysiological changes in relative power and MSE computed on the pre-stimulus and delay task time windows. Results indicated increases in repetition accuracy, decreases in contralateral theta (4–7 Hz) and coarse-scale MSE (slow activity), and increases in perilesional low-gamma (25–50 Hz) and fine-scale MSE (fast activity) after anodal-tDCS, indicating reversal of pathological abnormalities. RsMEG may be a sensitive measure for guiding therapeutic tDCS. |
| Databáze: | OpenAIRE |
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