Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress
| Autor: | Ying-Li Zhu, Cheng-Long Wang, Lin-Yuan Wang, Rui Zhang, Wen-Ting Fei, Jing-Xia Wang, Jian-Jun Zhang, Dan-Ping Zhao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Bridged-Ring Compounds
Male Restraint Physical medicine.medical_specialty Hippocampus Nitric Oxide 01 natural sciences Protein expression Antidepressant like Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Stress Physiological Neurotrophic factors Dopamine Internal medicine Drug Discovery medicine Animals Cyclic GMP Messenger RNA Depression 010405 organic chemistry Chemistry General Medicine Antidepressive Agents Rats 0104 chemical sciences Endocrinology Complementary and alternative medicine Receptors Serotonin 030220 oncology & carcinogenesis No signaling Restraint stress Signal Transduction medicine.drug |
| Zdroj: | Chinese Journal of Natural Medicines. 18:872-880 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(20)60030-9 |
| Popis: | The depressant-like effects of albiflorin (AF) were studied on stressed chronic restraint stress (CRS) rats. Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg·kg-1 of AF for 21 d. Control rats were maintained in completely non stressed conditions. Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF. Treatment with AF significantly restored the depressant-like behaviors. Besides, AF increased the levels of 5-hydroxytryptophan (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), noradrenaline (NE) and dopamine (DA) in the hippocampus and increased the level of brain-derived neurotrophic factor (BDNF) in serum and protein expression in hippocampus. In addition, AF decreased the levels of hypothalamo-pituitary-adrenal (HPA) cascade, reduced the level of NO and cGMP in serum and inhibited the overexpression of 5-HT2AR mRNA and protein expression. Taken together, AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like behaviors. These physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days. |
| Databáze: | OpenAIRE |
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