Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates
| Autor: | Ian N. Moore, Seyhan Boyoglu-Barnum, Swagata Kar, Bianca M. Nagata, Shayne F. Andrew, Joseph R. Francica, John R. Mascola, Shruti N. Shah, Darin K. Edwards, Samantha J. Provost, Barney S. Graham, John Paul Todd, Venkata Viswanadh Edara, Eun Sung Yang, Daniel Valentin, Katelyn Steingrebe, David C. Montefiori, Andrea Carfi, Maciel Porto, Hanne Leth Andersen, Robert A. Seder, Kizzmekia S. Corbett, Wei Shi, Jack Greenhouse, Mark G. Lewis, Evan Lamb, Adrian B. McDermott, Daniel C. Douek, Serge Zouantcha, Kathryn E. Foulds, Nancy J. Sullivan, Mahnaz Minai, Kevin W. Bock, Britta Flach, Lilin Lai, Katharine Floyd, Angela Choi, Charlene McDanal, Jonathan Fintzi, Alan Dodson, Matthew A. Koch, Mario Roederer, Amy T. Noe, Juan I. Moliva, Saule T. Nurmukhambetova, Mitzi M. Donaldson, Laurent Pessaint, Timothy S. Johnston, Andrew Faudree, Anne P. Werner, Mehul S. Suthar, Barbara J. Flynn, Kai Wu, Anthony L. Cook, Sarah O’Connell, Gabriela S. Alvarado, Lingshu Wang, Yi Zhang, Martha Nason, Dillon R. Flebbe, Matthew Gagne, Olubukola M. Abiona, Renee van de Wetering, Kwanyee Leung |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Multidisciplinary biology Surrogate endpoint business.industry Immunogenicity respiratory system Vaccine efficacy Article Vaccination 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Vaccine Potency Immunization Viral replication Immunology biology.protein Medicine 030212 general & internal medicine Antibody business |
| Zdroj: | Science |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.abj0299 |
| Popis: | Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. The nonhuman primate (NHP) model of SARS-CoV-2 infection replicates key features of human infection and may be used to define immune correlates of protection following vaccination. Here, NHP received either no vaccine or doses ranging from 0.3 - 100 μg of mRNA-1273, a mRNA vaccine encoding the prefusion-stabilized SARS-CoV-2 spike (S-2P) protein encapsulated in a lipid nanoparticle. mRNA-1273 vaccination elicited robust circulating and mucosal antibody responses in a dose-dependent manner. Viral replication was significantly reduced in bronchoalveolar lavages and nasal swabs following SARS-CoV-2 challenge in vaccinated animals and was most strongly correlated with levels of anti-S antibody binding and neutralizing activity. Consistent with antibodies being a correlate of protection, passive transfer of vaccine-induced IgG to naïve hamsters was sufficient to mediate protection. Taken together, these data show that mRNA-1273 vaccine-induced humoral immune responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP.mRNA-1273 vaccine-induced antibody responses are a mechanistic correlate of protection against SARS-CoV-2 infection in NHP. |
| Databáze: | OpenAIRE |
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