Effect of Avoidance on Peanut Allergy after Early Peanut Consumption

Autor: George, Du Toit, Peter H, Sayre, Graham, Roberts, Michelle L, Sever, Kaitie, Lawson, Henry T, Bahnson, Helen A, Brough, Alexandra F, Santos, Kristina M, Harris, Suzana, Radulovic, Monica, Basting, Victor, Turcanu, Marshall, Plaut, Gideon, Lack, Travis, Mason
Rok vydání: 2016
Předmět:
Zdroj: The New England journal of medicine. 374(15)
ISSN: 1533-4406
Popis: Background In a randomized trial, the early introduction of peanuts in infants at high risk for allergy was shown to prevent peanut allergy. In this follow-up study, we investigated whether the rate of peanut allergy remained low after 12 months of peanut avoidance among participants who had consumed peanuts during the primary trial (peanut-consumption group), as compared with those who had avoided peanuts (peanut-avoidance group). Methods: At the end of the primary trial, we instructed all the participants to avoid peanuts for 12 months. The primary outcome was the percentage of participants with peanut allergy at the end of the 12-month period, when the participants were 72 months of age. Results: We enrolled 556 of 628 eligible participants (88.5%) from the primary trial; 550 participants (98.9%) had complete primary-outcome data. The rate of adherence to avoidance in the follow-up study was high (90.4% in the peanut-avoidance group and 69.3% in the peanut-consumption group). Peanut allergy at 72 months was significantly more prevalent among participants in the peanut-avoidance group than among those in the peanut-consumption group (18.6% [52 of 280 participants] vs. 4.8% [13 of 270], PConclusions: Among children at high risk for allergy in whom peanuts had been introduced in the first year of life and continued until 5 years of age, a 12-month period of peanut avoidance was not associated with an increase in the prevalence of peanut allergy. Longer-term effects are not known. (Funded by the National Institute of Allergy and Infectious Diseases and others; LEAP-On ClinicalTrials.gov number, NCT01366846 .).
Databáze: OpenAIRE