Role of Vimentin and E-cadherin Expression in Premalignant and Malignant Lesions of Oral Cavity
Autor: | Pawan Singhal, Shashank Nath Singh, Prem Singh Jat, Ritu Sehra, Sunita Agarwal, Sandesh Kumar Gupta |
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Rok vydání: | 2021 |
Předmět: |
Pathology
medicine.medical_specialty biology medicine.diagnostic_test business.industry Cadherin Vimentin medicine.disease Metastasis Lesion 03 medical and health sciences 0302 clinical medicine Otorhinolaryngology 030220 oncology & carcinogenesis Biopsy medicine biology.protein Immunohistochemistry Surgery Lymph medicine.symptom 030223 otorhinolaryngology business Rest (music) |
Zdroj: | Indian Journal of Otolaryngology and Head & Neck Surgery. 74:350-355 |
ISSN: | 0973-7707 2231-3796 |
Popis: | To determine the role of Vimentin and E-cadherin expression in oral premalignant and malignant lesions. 68 histopathologically confirmed cases of premalignant and malignant oral cavity lesions enrolled. Biopsy specimens were taken from lesion of all cases and subjected to immunohistochemical evaluation of expression of E-cadherin and Vimentin. We examined the relationships between the expression of these markers and specific clinicopathological features were analyzed. Out of 68 cases 28 showed high vimentin expression (3 + and 4 + grade) and 40 showed low vimentin expression (1 + and 2 + grade). 20 cases out of 68 presented with high E-cadherin expression (3 + and 4 +) and rest 48 with low expression (1 + and 2 +) of the same. Smoking and tobacco chewing reflected non-significant association with their expression. In this study all 28 patients (100%) with high vimentin expression had malignant lesions and 17 (60.7%) presented with metastatic lymph nodes Out of 20 patients with high E-cadherin expression 8(40.0%) had malignant lesions and 12 (60.0%) had pre malignant lesions and 4 (20%) showed nodal metastasis. As tumor stage (TNM) progresses, it showed increased vimentin and decreased E-cadherin expression and vice versa. We concluded that increased vimentin and decreased E-cadherin expression in oral cancers are associated with metastasis and disease progression in terms of upstaging of disease. We can use cellular expression of vimentin and E-cadherin for early diagnosis of disease. |
Databáze: | OpenAIRE |
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