Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes

Autor: Nuria Vilarrasa, Silvia Pellitero, Anna Casajoana, Amador García Ruiz de Gordejuela, Jordi Pujol Gebelli, Rafael López-Urdiales, Joan Vendrell, Elsa Maymó-Masip, Sonia Fernández-Veledo, Nuria de la Morena, Miriam Ejarque, Manuel Pérez-Maraver, Nuria Virgili, Fernando Guerrero-Pérez
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Blood Glucose
Male
medicine.medical_treatment
Adipose tissue
lcsh:Medicine
Bariatric Surgery
Type 2 diabetes
Morbid obesity
0302 clinical medicine
Weight loss
Glucose homeostasis
lcsh:Science
Multidisciplinary
Diabetis
Stomach
digestive
oral
and skin physiology
Diabetes
Fasting
Middle Aged
Obesity
Morbid
Adipose Tissue
Female
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
Adult
medicine.medical_specialty
Sleeve gastrectomy
endocrine system
Adolescent
Gastric Bypass
Obesitat mòrbida
Incretin
Incretins
Article
Glucagon-Like Peptide-1 Receptor
03 medical and health sciences
Stomach surgery
Young Adult
Gastrectomy
Diabetes mellitus
Weight Loss
medicine
Humans
Obesity
business.industry
lcsh:R
medicine.disease
Surgery
030104 developmental biology
Diabetes Mellitus
Type 2
lcsh:Q
business
030217 neurology & neurosurgery
Zdroj: Scientific Reports
Dipòsit Digital de la UB
Universidad de Barcelona
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
ISSN: 2045-2322
Popis: We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. GLP-1R expression was higher in VAT than in SAT. GLP-1R expression in VAT correlated with weight (r = −0.453, p = 0.008), waist circumference (r = −0.494, p = 0.004), plasma insulin (r = −0.466, p = 0.007), and systolic blood pressure (BP) (r = −0.410, p = 0.018). At 1 year, GLP-1R expression in VAT was negatively associated with diastolic BP (r = −0.361, p = 0.039) and, following metabolic gastric bypass, with the increase of GLP-1 AUC, (R2 = 0.46, p = 0.038). Finally, GLP-1R in AT was similar independently of diabetes outcomes and was not associated with weight loss after surgery. Thus, GLP-1R expression in AT is of limited value to predict incretin response and does not play a role in metabolic outcomes after bariatric surgery.
Databáze: OpenAIRE
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