Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes
Autor: | Nuria Vilarrasa, Silvia Pellitero, Anna Casajoana, Amador García Ruiz de Gordejuela, Jordi Pujol Gebelli, Rafael López-Urdiales, Joan Vendrell, Elsa Maymó-Masip, Sonia Fernández-Veledo, Nuria de la Morena, Miriam Ejarque, Manuel Pérez-Maraver, Nuria Virgili, Fernando Guerrero-Pérez |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Blood Glucose Male medicine.medical_treatment Adipose tissue lcsh:Medicine Bariatric Surgery Type 2 diabetes Morbid obesity 0302 clinical medicine Weight loss Glucose homeostasis lcsh:Science Multidisciplinary Diabetis Stomach digestive oral and skin physiology Diabetes Fasting Middle Aged Obesity Morbid Adipose Tissue Female medicine.symptom hormones hormone substitutes and hormone antagonists Adult medicine.medical_specialty Sleeve gastrectomy endocrine system Adolescent Gastric Bypass Obesitat mòrbida Incretin Incretins Article Glucagon-Like Peptide-1 Receptor 03 medical and health sciences Stomach surgery Young Adult Gastrectomy Diabetes mellitus Weight Loss medicine Humans Obesity business.industry lcsh:R medicine.disease Surgery 030104 developmental biology Diabetes Mellitus Type 2 lcsh:Q business 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports Dipòsit Digital de la UB Universidad de Barcelona r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
ISSN: | 2045-2322 |
Popis: | We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. GLP-1R expression was higher in VAT than in SAT. GLP-1R expression in VAT correlated with weight (r = −0.453, p = 0.008), waist circumference (r = −0.494, p = 0.004), plasma insulin (r = −0.466, p = 0.007), and systolic blood pressure (BP) (r = −0.410, p = 0.018). At 1 year, GLP-1R expression in VAT was negatively associated with diastolic BP (r = −0.361, p = 0.039) and, following metabolic gastric bypass, with the increase of GLP-1 AUC, (R2 = 0.46, p = 0.038). Finally, GLP-1R in AT was similar independently of diabetes outcomes and was not associated with weight loss after surgery. Thus, GLP-1R expression in AT is of limited value to predict incretin response and does not play a role in metabolic outcomes after bariatric surgery. |
Databáze: | OpenAIRE |
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