A Study of Vitamin D Supplementation to Patients with Chronic Diseases Admitted to Ain Shams University Hospital
Autor: | Hany Khairy Mansour, Mariam Michel Ayad Grace, Raef Malak Botros, Ahmed Mohamed Bahaa El Din |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Vitamin d supplementation business.industry Hospitalized patients Case-control study General Medicine Intervention group 030204 cardiovascular system & hematology medicine.disease University hospital vitamin D deficiency 03 medical and health sciences Chronic disease 0302 clinical medicine Heart failure Internal medicine medicine Vitamin D and neurology 030212 general & internal medicine business |
Zdroj: | The Egyptian Journal of Hospital Medicine. 81:2165-2172 |
ISSN: | 2090-7125 |
Popis: | Background Vitamin D deficiency and insufficiency have become a common problem worldwide. Vitamin D has been associated with all causes of mortality in chronic diseases and associated with a longer hospital stay and poor outcome. Aim of the Study to evaluate the role of vitamin D supplementation on the outcome of hospitalization for patients with CLD or CHF admitted to Ain Shams University Hospitals (ASUH) with acute deterioration of their illness. Subjects and methods We conducted prospective case control on 80 patients collected from inpatient ward of endocrinology, divided into 2 groups; 40 patients with chronic liver diseases and 40 patients with heart failure. Serum 25OH-vitamin D and calcium, phosphate and PTH were measured to all participants before intervention. 20 patients of each group (Intervention group) received single dose of vitamin D within 3 days of admission and the other 20 patients of each group (control group) did not receive vitamin D vitamin D. Results no significant difference between patients who received vitamin D supplementation and who did not receive vitamin D supplementation as regards outcome and survival with P value 1.000 in patients with CLD and 0.823 in patients with CHF. On the other hand, we found baseline vitamin D level was an independent predictor of mortality (P value .018). Conclusion We found that a beneficial effect of vitamin D supplementation can't be achieved with single dose vitamin D (200,000 IU) on CHF or CLD hospitalized patients’ mortality. We recommend that vitamin D supplementation should be considered in CLD and CHF outpatients, with exception of hypercalcemic and hyperphosphatemic patients, as baseline vitamin D status affects the disease course and mortality prior to disease deterioration and hospitalization. |
Databáze: | OpenAIRE |
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