Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding
| Autor: | Jorge Fonseca, Elisabete Carolino, António Sousa Guerreiro, Carla Adriana Santos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Deglutition Disorders/physiopathology HSM MED medicine.medical_treatment Enteral feeding Critical Care and Intensive Care Medicine Gastroenterology Enteral administration Deficiency Diseases/etiology 0302 clinical medicine 030212 general & internal medicine Prospective Studies chemistry.chemical_classification Aged 80 and over Gastrostomy Nutrition and Dietetics Trace Elements/deficiency biology Deficiency Diseases/prevention & control Dysphagia Middle Aged Blood proteins Combined Modality Therapy Deglutition Disorders/therapy Deficiency Diseases/epidemiology Protein-Energy Malnutrition/diagnosis Portugal/epidemiology Female Adult Risk medicine.medical_specialty Deglutition Disorders/surgery Serum albumin Nutritional Status Clinical nutrition Trace Elements/blood Protein-Energy Malnutrition Protein-Energy Malnutrition/etiology 03 medical and health sciences Young Adult Enteral Nutrition Internal medicine PEG ratio medicine Humans Aged Nutrition Protein-Energy Malnutrition/epidemiology Trace elements 030109 nutrition & dietetics Portugal business.industry Spectrophotometry Atomic Albumin PEG Surgery Trace Elements Nutrition Assessment chemistry Transferrin Protein-Energy Malnutrition/prevention & control biology.protein Deficiency Diseases/diagnosis Deglutition Disorders/blood business Deficiency Diseases Deglutition Disorders Biomarkers/blood Biomarkers |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação |
| Popis: | summary Background & aims: Patients who underwent endoscopic gastrostomy (PEG) present protein-energy malnutrition, but little is known about Trace Elements (TE), Zinc (Zn), Copper (Cu), Selenium (Se), Iron (Fe), Chromium (Cr). Our aim was the evaluation of serum TE in patients who underwent PEG and its relationship with serum proteins, BMI and nature of underlying disorder. Methods: A prospective observational study was performed collecting: patient's age, gender, underlying disorder, NRS-2002, BMI, serum albumin, transferrin and TE concentration. We used ferrozine colorimetric method for Fe; Inductively Coupled Plasma-Atomic Emission Spectroscopy for Zn/Cu; Furnace Atomic Absorption Spectroscopy for Se/Cr. The patients were divided into head and neck cancer (HNC) and neurological dysphagia (ND). Results: 146 patients (89 males), 21e95 years: HNC-56; ND-90. Low BMI in 78. Low values mostly for Zn (n ¼ 122) and Fe (n ¼ 69), but less for Se (n ¼ 31), Cu (n ¼ 16), Cr (n ¼ 7); low albumin in 77, low transferrin in 94 and 66 with both proteins low. Significant differences between the groups of underlying disease only for Zn (t 140.326 ¼� 2,642, p < 0.01) and a correlation between proteins and TE respectively albumin and Zn (r ¼ 0.197, p ¼ 0.025), and albumin and Fe (r ¼ 0.415, p ¼ 0.000). Conclusions: When gastrostomy was performed, patients display low serum TE namely Zn, but also Fe, less striking regarding others TE. It was related with prolonged fasting, whatever the underlying disease. Low proteins were associated with low TE. Teams taking care of PEG-patients should use Zn supplementation and include other TE evaluation as part of the nutritional assessment of PEG candidates. © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|