Theanine enhanced both the toxicity of strychnine and anticonvulsion of pentobarbital sodium
| Autor: | Bo-La Wu, Wei Yang, Jin-Chao Gao, Xi-Chong Yu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Pentobarbital medicine.drug_class Health Toxicology and Mutagenesis Pharmacology Toxicology Lethal Dose 50 Hypnotic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glutamates Seizures medicine Animals Hypnotics and Sedatives Drug Interactions Mice Inbred ICR Chemical Health and Safety Dose-Response Relationship Drug GABAA receptor Public Health Environmental and Occupational Health Electroencephalography Strychnine General Medicine Theanine 030104 developmental biology chemistry Glycine NMDA receptor Female Caffeine 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Drug and Chemical Toxicology. 39:217-223 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.3109/01480545.2015.1080264 |
| Popis: | Theanine, an additive, holds several effects on the central nervous system without toxicity and affects CNS drugs. Theanine bilaterally alters β wave of the EEG with or without caffeine and pentobarbital-induced locomotor activity. Theanine also enhances hypnosis of pentobarbital sodium (PB) and antidepression of midazolam, suggesting there are complicated interactions between theanine and CNS drugs. On the other side, theanine induces glycine release. Glycine potentiates the strychnine toxicity via NMDA receptor activation. Moreover, PB facilitates GABAA receptor activation by GABA, and it is commonly prescribed for strychnine poison. However, what the role that theanine plays in the anticonvulsion of PB against strychnine poison is still unknown.Theanine, pentobarbital sodium or strychnine was injected intraperitoneally. EEG was monitored by BIOPAC 16 EEG amplifiers. LD50 of strychnine and hypnotic ED50 of pentobarbital sodium with or without theanine for mice were tested according to Bliss' case.(1) Theanine enhanced the strychnine toxicity. Both theanine and strychnine 1.0 mg/kg increased the power of the β wave. Theanine aggravated that of strychnine 1.0 mg/kg. Theanine attenuated the LD50 of strychnine. (2) Theanine enhanced the anticonvulsion of PB. Theanine increased the power of α, β wave and decreased hypnotic ED50 of PB; PB attenuated strychnine-induced EEG excitation and mortality with or without theanine, and theanine enhanced the effects of PB. Further, theanine enhanced the anticonvulsion of PB dose-dependently against the strychnine toxicity but not the lethal toxicity of strychnine.These results indicated theanine interacted with PB and strychnine. Theanine enhanced both the strychnine toxicity and anticonvulsion of PB against strychnine poison. |
| Databáze: | OpenAIRE |
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