Evaluation of amphetamine-induced hyperlocomotion and catalepsy following long-acting risperidone administration in rats
| Autor: | Gianluca Casu, Giorgio Marchese, Gabriele Pinna Spada, Paola Casti, Luca Pani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Time Factors medicine.drug_class Chemistry Pharmaceutical medicine.medical_treatment Atypical antipsychotic Hyperkinesis Motor Activity Catalepsy Pharmacology Rats Sprague-Dawley Amphetamine Antipsychotic Long-acting Risperidone Long acting risperidone Reaction Time medicine Animals Behavior Animal Dopamine antagonist medicine.disease Rats Psychology Amfetamine Antipsychotic Agents medicine.drug |
| Zdroj: | European journal of pharmacology 620 (2009): 36–41. doi:10.1016/j.ejphar.2009.07.024 info:cnr-pdr/source/autori:Marchese G a,b; Casu G b; Casti P b; Spada GP b; Pani L a,b/titolo:Evaluation of amphetamine-induced hyperlocomotion and catalepsy following long-acting risperidone administration in rats./doi:10.1016%2Fj.ejphar.2009.07.024/rivista:European journal of pharmacology/anno:2009/pagina_da:36/pagina_a:41/intervallo_pagine:36–41/volume:620 |
| DOI: | 10.1016/j.ejphar.2009.07.024 |
| Popis: | It has been proposed that long-acting risperidone could provide a constant antipsychotic efficacy associated with a reduced liability to induce extra-pyramidal symptoms. To ascertain this hypothesis, antagonism of amphetamine-induced hyperlocomotion and catalepsy were analyzed in rats for a period of 1-6 weeks following long-acting risperidone (20-60 mg/kg) injection. Long-acting risperidone reduced amphetamine-induced hyperlocomotion after 2-5 weeks from drug injection, without producing significant extra-pyramidal symptoms. Following the administration of long-acting risperidone a constant ability to antagonize amphetamine-induced hyperlocomotion was observed during the day, but not when the antipsychotic was chronically administered using a short-acting formulation. The pre-clinical results confirmed that long-acting risperidone may represent an advance in antipsychotic therapy. |
| Databáze: | OpenAIRE |
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