Age and diet modify acute microhemorrhage outcome in the mouse brain
| Autor: | Thavarak Ouk, Michèle Bastide, Régis Bordet, Vincent Bérézowski, Olivier Pétrault, Maud Pétrault |
|---|---|
| Přispěvatelé: | Université de Lille, Université d'Artois (UA), Laboratoire de la Barrière Hémato-Encéphalique (LBHE) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Aging Normal diet [SDV]Life Sciences [q-bio] Motor Disorders Physiology Motor Activity Diet High-Fat Asymptomatic Vascular health Mice 03 medical and health sciences Cognition 0302 clinical medicine Risk Factors Animals Medicine Cognitive decline Cerebral Hemorrhage Cognitive Symptoms Working memory business.industry General Neuroscience Prognosis Visual recognition 030104 developmental biology Acute Disease Neurology (clinical) Geriatrics and Gerontology medicine.symptom Cognition Disorders business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiology of Aging Neurobiology of Aging, 2021, 98, pp.99-107. ⟨10.1016/j.neurobiolaging.2020.10.005⟩ Neurobiology of Aging, Elsevier, 2021, 98, pp.99-107. ⟨10.1016/j.neurobiolaging.2020.10.005⟩ |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2020.10.005⟩ |
| Popis: | Cerebral microhemorrhages (CMHs) are considered as asymptomatic lesions, but might impair cognition in non-demented elderly individuals. The aging process includes poor vascular health, enhanced at midlife by metabolic disturbances upon high-fat diet (HFD). The onset of CMHs could thus have more serious consequences in midlife subjects with metabolic disturbances. This hypothesis was tested through the induction of multiple CMHs, using cyclodextrin nanoparticles injection, in mice at midlife (14 month old) or at a younger stage (5 month old) after 12 months or 3 months of normal diet or HFD (40% of animal fat) respectively. When induced at 14 months of age, CMHs were not larger but were more numerous (+25%) in mice on HFD compared with mice on normal diet. They slowed down the locomotor activity significantly but caused neither a change in the working memory nor a difference in the visual recognition memory decline. When induced at 5 months of age, CMHs provoked slighter locomotor and cognitive symptoms, regardless the diet. No spontaneous progression of CMHs toward larger hemorrhages was observed after onset when HFD was prolonged up to midlife. Consistently, no precipitated cognitive decline was observed. Middle-age plus time of metabolic disturbances represent enhanced risk factors for CMH outcome. |
| Databáze: | OpenAIRE |
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