Evidences for adult hippocampal neurogenesis in humans
| Autor: | Elena P. Moreno-Jiménez, Julia Terreros-Roncal, Miguel Flor-García, María Llorens-Martín, Alberto Rábano |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Alzheimer's Association, Association for Frontotemporal Degeneration (US), Comunidad de Madrid, Fundación Ramón Areces, Banco Santander |
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Neurogenesis Controversy Hippocampus Hippocampal formation Biology Adult neurogenesis Immature neuron 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Neuroplasticity medicine Humans In patient Neuronal Plasticity Human studies General Neuroscience Dentate gyrus Age Factors Methodology Dual Perspectives Human brain 030104 developmental biology medicine.anatomical_structure Neuroscience 030217 neurology & neurosurgery Human |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname J Neurosci |
| Popis: | The rodent hippocampus generates new neurons throughout life. This process, named adult hippocampal neurogenesis (AHN), is a striking form of neural plasticity that occurs in the brains of numerous mammalian species. Direct evidence of adult neurogenesis in humans has remained elusive, although the occurrence of this phenomenon in the human dentate gyrus has been demonstrated in seminal studies and recent research that have applied distinct approaches to birthdate newly generated neurons and to validate markers of adult-born neurons. Our data point to the persistence of AHN until the 10th decade of human life, as well as to marked impairments in this process in patients with Alzheimer's disease. Moreover, our work demonstrates that the methods used to process and analyze postmortem human brain samples can limit the detection of various markers of AHN to the point of making them undetectable. In this Dual Perspectives article, we highlight the critical methodological aspects that should be strictly controlled in human studies and the robust evidence that supports the occurrence of AHN in humans. We also put forward reasons that may account for current discrepancies on this topic. Finally, the unresolved questions and future challenges awaiting the field are highlighted. Spanish Ministry of Economy and Competitiveness SAF-2017-82185-R and RYC-2015-171899 to M.L.-M., Alzheimer’s Association 2015-NIRG-340709 and AARG-17-528125 to M.L.-M., Association for Frontotemporal Degeneration 2016 Basic Science Pilot Grant Award to M.L.-M., and Comunidad de Madrid PEJD-2017-PRE/BMD-3439 to M.L.-M. Institutional grants from Fundación Ramón Areces and Banco de Santander to Centro de Biología Molecular “Severo Ochoa |
| Databáze: | OpenAIRE |
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