Signalling pathways that regulate endothelial differentiation from stem cells
| Autor: | Wen Wang, Qingbo Xu, Zhenling Luo, Gang Wang, Qingzhong Xiao |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Endothelium
Vascular disease Stem Cells Cell Differentiation Biology medicine.disease Regenerative Medicine Embryonic stem cell Regenerative medicine Cyclic AMP-Dependent Protein Kinases Histone Deacetylases Cell biology Cell therapy Endothelial stem cell Wnt Proteins medicine.anatomical_structure Transforming Growth Factor beta medicine Humans Endothelium Vascular Signal transduction Stem cell Embryonic Stem Cells Signal Transduction |
| Zdroj: | Frontiers in bioscience (Landmark edition). 16(2) |
| ISSN: | 2768-6698 |
| Popis: | Endothelial cells play a vital role in the human vascular system. Injury to this layer of cells can lead to devastating consequences and eventually mortality. As demonstrated by recent accumulating evidences, the injured endothelial layer can be rescued by endothelial cell-based therapy. However, the limited source of functional endothelial cells which can be used in clinical surgery, is hugely hampered. The discovery of pluripotent embryonic stem cells, nevertheless has raised hope for generating endothelial cells in the regenerative medicine field. It was demonstrated that the concerted and coordinated series of specific signaling pathways involving different molecules, guide the differentiation of these embryonic stem cells into functional endothelial cells. Moreover, it is believed that understanding the molecular mechanisms of endothelial development and signal pathways leading to endothelial differentiation from stem cells, will be essential for potential cell therapy for vascular disease. This review therefore, will summarize and discuss recent insights into endothelial development and the signaling pathways regulating embryonic stem cell differentiation towards the endothelial lineage. |
| Databáze: | OpenAIRE |
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