A dynamic model of a two-synapse feedback loop in the vertebrate retina
| Autor: | John D. Abernethy |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Frequency response
Retina Quantitative Biology::Neurons and Cognition Models Neurological General Medicine Feedback loop Feedback Loop (topology) Synapse medicine.anatomical_structure Control theory Negative feedback Synapses Psychophysics medicine Animals Humans Graded potential Anura Harmonic oscillator Mathematics |
| Zdroj: | Kybernetik. 14:187-200 |
| ISSN: | 0023-5946 |
| DOI: | 10.1007/bf00274805 |
| Popis: | The theoretical properties of synapses such as those in the retina which operate on graded potentials are developed using work on tetrodotoxin-treated synapses as a basis. A linearized model of a two-synapse negative feedback loop analogous to the bipolaramacrine feedback loop in the retina possesses a frequency response which developes an increasingly prominent resonance peak at higher input levels and under some circumstances shows instability. Psychophysical studies have shown that the visual system also exhibits this behaviour suggestive of progressive underdamping in a harmonic oscillator. Evidence in favor of the hypothesis that resonance originates in the loop is presented, the conclusions being that the loop functions to tune the retina to a range of temporal frequencies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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