Colistin resistance in carbapenemase-producing Klebsiella pneumoniae bloodstream isolates: Evolution over 15 years and temporal association with colistin use by time series analysis
| Autor: | Joseph Papaparaskevas, Michael Samarkos, George L. Daikos, Angeliki Pantazatou, Antonios Markogiannakis, Mina Balaska, Giannoula S. Tansarli, Marina Mantzourani, Katerina Polonyfi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Time Factors Klebsiella pneumoniae 030106 microbiology Microbial Sensitivity Tests Tigecycline Fosfomycin Meropenem beta-Lactamases Agar dilution Microbiology 03 medical and health sciences Bacterial Proteins Drug Resistance Bacterial polycyclic compounds medicine Humans Pharmacology (medical) Cross Infection Greece biology Colistin business.industry Broth microdilution General Medicine biochemical phenomena metabolism and nutrition equipment and supplies bacterial infections and mycoses biology.organism_classification medicine.disease Anti-Bacterial Agents Klebsiella Infections Carbapenem-Resistant Enterobacteriaceae Infectious Diseases Bacteremia lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | International Journal of Antimicrobial Agents. 52:397-403 |
| ISSN: | 0924-8579 |
| Popis: | Colistin is often the only available treatment option against infections caused by carbapenemase-producing Klebsiella pneumoniae (CP-Kp). In this study, the evolution of colistin resistance among CP-Kp and its relationship with colistin use in a tertiary-care hospital in Athens, Greece, was investigated. All CP-Kp blood isolates recovered between January 2002 and June 2016 were tested for susceptibility to colistin by agar dilution and broth microdilution methods. Data on colistin use were collected from the pharmacy database. Time series of colistin use and resistance were analysed using the Box and Jenkins method. A transfer function model was built to quantify the dynamic relationship between colistin use and resistance. Overall, 313 CP-Kp isolates were identified. The percentage colistin resistance increased from 0% in 2002 to 26.9% in 2016 (R2 = 0.5, P |
| Databáze: | OpenAIRE |
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