Proliferative leukoplakia: Proposed new clinical diagnostic criteria
| Autor: | F. de Abreu Alves, Reshma S. Menon, David Ojeda, Alexander Ross Kerr, Alessandro Villa, Sook-Bin Woo, André Guollo |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythema Hyperkeratosis Lesion 03 medical and health sciences 0302 clinical medicine medicine Humans Family history General Dentistry Leukoplakia Aged Retrospective Studies Mouth neoplasm Aged 80 and over business.industry Retrospective cohort study 030206 dentistry Middle Aged medicine.disease Dermatology Cell Transformation Neoplastic Otorhinolaryngology Dysplasia 030220 oncology & carcinogenesis Female Mouth Neoplasms medicine.symptom Leukoplakia Oral business |
| Zdroj: | Oral diseases. 24(5) |
| ISSN: | 1601-0825 |
| Popis: | Objective We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathological standpoint and suggest an updated classification. Subjects and methods Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathological features and malignant transformation (MT). Results There were 42 patients (median age: 69 years [range: 36-88]; 35 females). 12.2% were current smokers. Family history of cancer was present in 43.7% of patients. Partial demarcation of lesion margins was present in 31.3% of lesions, followed by verrucous (27.5%), smooth (22.7%) erythematous (22.3%), and fissured (18.3%) appearance. Large and contiguous and multisite and non-contiguous lesions comprised 57.1% (24/42) and 35.7% (15/42) of PVL cases, respectively. 19.1% had prominent erythema (erythroleukoplakia). The most common histopathological diagnosis at first visit was hyperkeratosis without dysplasia (22/42; 56.4%). MT occurred in 71.4% patients after a median of 37 months [range: 1-210] from initial visit; erythroleukoplakia exhibited MT in 100% of cases. Conclusion The generic term "proliferative leukoplakia (PL)" may be more appropriate than PVL because 18.3% were fissured and 22.7% erythematous. We also propose the term proliferative erythroleukoplakia to more accurately describe the subset of PL with prominent erythema, which had the highest MT rate. |
| Databáze: | OpenAIRE |
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