HPTLC Fingerprint Profile and Identification of Antidiabetic and Antioxidant Leads from Bauhinia rufescens L
| Autor: | Abdel Khalig Muddathir, Iman H. Abdoon, Shaza W. Shantier, Mona Salih Mohammed, Hassan S. Khalid, Bashier Osman, Wadah J. A. Osman |
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| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
Article Subject biology Traditional medicine Hptlc fingerprint Chemistry medicine.medical_treatment Organic Chemistry 030209 endocrinology & metabolism Bauhinia rufescens RM1-950 biology.organism_classification Biochemistry 03 medical and health sciences Health problems 0302 clinical medicine 030220 oncology & carcinogenesis medicine Pharmacology (medical) Therapeutics. Pharmacology General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Advances in Pharmacological and Pharmaceutical Sciences, Vol 2020 (2020) |
| ISSN: | 2633-4690 2633-4682 |
| DOI: | 10.1155/2020/3201463 |
| Popis: | Diabetes is one of the world’s major health problems, and many reports have supported the role of oxidative stress in the pathogenesis of both type 1 and type 2 diabetes. The present study aims to evaluate the antidiabetic and antioxidant activity of Bauhinia rufescens, a plant used in Sudanese folkloric medicine for the treatment of diabetes. It was also aimed to identify isolates and characterize the bioactive antidiabetic and antioxidant compounds using bioactivity-guided fractionation followed by high-performance thin-layer chromatography (HPTLC) autobiography, liquid chromatography-mass spectrometric analysis, and nuclear magnetic resonance (NMR). Two potential compounds were successfully isolated and identified which may provide new leads for more potent analogues in drug discovery. |
| Databáze: | OpenAIRE |
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